ArticlePloS one2010
Insect repellents: modulators of mosquito odorant receptor activity.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- A systematic review of mosquito coils and passive emanators: defining recommendations for spatial repellency testing methodologies.Parasites & vectors · 2012Pooled it
- Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil.Insect molecular biology · 2026Article
- Article
- Review
- Integrated strategies for mosquito-borne disease control: a comprehensive review with emphasis on repellents and China's practices.Parasites & vectors · 2026Review
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- The Evolving Landscape of Malaria Prevention Strategies: A Review of Recent Developments.Pathogens (Basel, Switzerland) · 2026Review
- In the arm-in-cage test, topical repellents activate mosquitoes to disengage upon contact instead of repelling them at distance.Scientific reports · 2024Article
- The behaviour of adult Anopheles gambiae, sub-Saharan Africa's principal malaria vector, and its relevance to malaria control: a review.Malaria journal · 2024Review
- Unveiling Molecular Effects of the Secondary Metabolite 2-Dodecanone in the Model HymenopteranToxics · 2024Article
- Study on SH-SY5Y autophagy inhibition and apoptosis induced by methanol extract ofToxicology research · 2024Article
- A critical review of current laboratory methods used to evaluate mosquito repellents.Frontiers in insect science · 2024Review
- Differentiation of action mechanisms between natural and synthetic repellents through neuronal electroantennogram and proteomic in Aedes aegypti (Diptera: Culicidae).Scientific reports · 2022Article
- Essential Oils: Useful Tools in Storage-Pest Management.Plants (Basel, Switzerland) · 2022Article
- The ovipositor cue indole inhibits animal host attraction in Aedes aegypti (Diptera: Culicidae) mosquitoes.Parasites & vectors · 2022Article
- Hierarchical Virtual Screening and Binding Free Energy Prediction of Potential Modulators of Aedes Aegypti Odorant-Binding Protein 1.Molecules (Basel, Switzerland) · 2022Article
- Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis ofInternational journal of molecular sciences · 2022Article
- The Bacillary Postbiotics, Including 2-Undecanone, Suppress the Virulence of Pathogenic Microorganisms.Pharmaceutics · 2022Article
- Sodium channel activation underlies transfluthrin repellency in Aedes aegypti.PLoS neglected tropical diseases · 2021Article
- Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.Molecular biology reports · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDEET, 2-undecanone (2-U), IR3535 and Picaridin are widely used as insect repellents to prevent interactions between humans and many arthropods including mosquitoes. Their molecular action has only recently been studied, yielding seemingly contradictory theories including odorant-dependent inhibitory and odorant-independent excitatory activities on insect olfactory sensory neurons (OSNs) and odorant receptor proteins (ORs). METHODOLOGY/PRINCIPAL
findingsHere we characterize the action of these repellents on two Aedes aegypti ORs, AaOR2 and AaOR8, individually co-expressed with the common co-receptor AaOR7 in Xenopus oocytes; these ORs are respectively activated by the odors indole (AaOR2) and (R)-(-)-1-octen3-ol (AaOR8), odorants used to locate oviposition sites and host animals. In the absence of odorants, DEET activates AaOR2 but not AaOR8, while 2-U activates AaOR8 but not AaOR2; IR3535 and Picaridin do not activate these ORs. In the presence of odors, DEET strongly inhibits AaOR8 but not AaOR2, while 2-U strongly inhibits AaOR2 but not AaOR8; IR3535 and Picaridin strongly inhibit both ORs. CONCLUSIONS/SIGNIFICANCE: These data demonstrate that repellents can act as olfactory agonists or antagonists, thus modulating OR activity, bringing concordance to conflicting models.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.