ArticleJournal of nucleic acids2010
A toolbox for predicting g-quadruplex formation and stability.
Article in Journal of nucleic acids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- QuaDB: A streamlined web tool for identifier-based rapid prediction of putative quadruplex sequences.Human genomics · 2026Article
- Stability of non-canonical nucleic acid structure as a potential modulator of cell fate.Nucleic acids research · 2026Review
- Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life.Genome research · 2025Article
- Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI.Toxins · 2022Article
- ONQUADRO: a database of experimentally determined quadruplex structures.Nucleic acids research · 2022Article
- Chromatin Hubs: A biological and computational outlook.Computational and structural biotechnology journal · 2022Review
- The effect of hairpin loop on the structure and gene expression activity of the long-loop G-quadruplex.Nucleic acids research · 2021Article
- G-Quadruplex Structures in Bacteria: Biological Relevance and Potential as an Antimicrobial Target.Journal of bacteriology · 2021Review
- How bioinformatics resources work with G4 RNAs.Briefings in bioinformatics · 2021Review
- Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back.Nucleic acids research · 2020Article
- Structure of two G-quadruplexes in equilibrium in the KRAS promoter.Nucleic acids research · 2020Article
- G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome.iScience · 2019Article
- G4Hunter web application: a web server for G-quadruplex prediction.Bioinformatics (Oxford, England) · 2019Article
- G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.Current medicinal chemistry · 2019Review
- Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter.Nucleic acids research · 2017Article
- A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect.Molecular therapy. Nucleic acids · 2017Article
- High-resolution three-dimensional NMR structure of theThe Journal of biological chemistry · 2017Article
- RNA G-quadruplexes: emerging mechanisms in disease.Nucleic acids research · 2017Article
- Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?Biochemical Society transactions · 2016Article
- G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-Hairpin-Duplex switch.Nucleic acids research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.