ArticleJournal of nucleic acids2010
"One Ring to Bind Them All"-Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles.
Article in Journal of nucleic acids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells.Nucleic acids research · 2021Article
- Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions inScientific reports · 2018Article
- TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.Nucleic acids research · 2018Article
- Telomerase as a Cancer Target. Development of New Molecules.Current topics in medicinal chemistry · 2016Review
- Human telomerase inhibitors from microbial source.World journal of microbiology & biotechnology · 2015Review
- The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex.Frontiers in chemistry · 2014Article
- HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A collection of 26 polyammonium cyclophane-type macrocycles with a large structural diversity has been screened for G-quadruplex recognition. A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of macrocycles of high affinity (DeltaT(1/2) up to 30 degrees C) and high selectivity for the human telomeric G-quadruplex. The four selected hits possess sophisticated architectures, more particularly the presence of a pendant side-arm as well as the existence of a particular topological arrangement appear to be strong determinants of quadruplex binding. These compounds are thus likely to create multiple contacts with the target that may be at the origin of their high selectivity, thereby suggesting that this class of macrocycles offers unique advantages for targeting G-quadruplex-DNA.
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Registered trials
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