ArticleFrontiers in cellular neuroscience2010
Temporal coding at the immature depolarizing GABAergic synapse.
Article in Frontiers in cellular neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
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- Delaying the GABA Shift Indirectly Affects Membrane Properties in the Developing Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- On the accuracy of cell-attached current-clamp recordings from cortical neurons.Frontiers in molecular neuroscience · 2022Article
- Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability.PLoS computational biology · 2021Article
- Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons.PLoS computational biology · 2021Article
- When Are Depolarizing GABAergic Responses Excitatory?Frontiers in molecular neuroscience · 2021Review
- GABAergic interneurons excite neonatal hippocampus in vivo.Science advances · 2020Article
- Giant Depolarizing Potentials Trigger Transient Changes in the Intracellular ClFrontiers in cellular neuroscience · 2018Article
- Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits.Frontiers in cellular neuroscience · 2017Review
- Uncorrelated Neural Firing in Mouse Visual Cortex during Spontaneous Retinal Waves.Frontiers in cellular neuroscience · 2017Article
- Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference.PLoS computational biology · 2016Article
- GABAergic Synchronization in Epilepsy.Cold Spring Harbor perspectives in medicine · 2016Review
- Dynamic Changes from Depolarizing to Hyperpolarizing GABAergic Actions during Giant Depolarizing Potentials in the Neonatal Rat Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo.Nature communications · 2015Article
- Depolarizing GABA and developmental epilepsies.CNS neuroscience & therapeutics · 2015Review
- Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.Epilepsy research · 2015Article
- Ontogeny of kainate-induced gamma oscillations in the rat CA3 hippocampus in vitro.Frontiers in cellular neuroscience · 2015Article
- Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the developing hippocampus, GABA exerts depolarizing and excitatory actions and contributes to the generation of neuronal network driven giant depolarizing potentials (GDPs). Here, we studied spike time coding at immature GABAergic synapses and its impact on synchronization of the neuronal network during GDPs in the neonatal (postnatal days P2-6) rat hippocampal slices. Using extracellular recordings, we found that the delays of action potentials (APs) evoked by synaptic activation of GABA(A) receptors are long (mean, 65 ms) and variable (within a time window of 10-200 ms). During patch-clamp recordings, depolarizing GABAergic responses were mainly subthreshold and their amplification by persistent sodium conductance was required to trigger APs. AP delays at GABAergic synapses shortened and their variability reduced with an increase in intracellular chloride concentration during whole-cell recordings. Negative shift of the GABA reversal potential (E(GABA)) with low concentrations of bumetanide, or potentiation of GABA(A) receptors with diazepam reduced GDPs amplitude, desynchronized neuronal firing during GDPs and slowed down GDPs propagation. Partial blockade of GABA(A) receptors with bicuculline increased neuronal synchronization and accelerated GDPs propagation. We propose that spike timing at depolarizing GABA synapses is determined by intracellular chloride concentration. At physiological levels of intracellular chloride GABAergic depolarization does not reach the action potential threshold and amplification of GABAergic responses by non-inactivating sodium conductance is required for postsynaptic AP initiation. Slow and variable excitation at GABAergic synapse determines the level of neuronal synchrony and the rate of GDPs propagation in the developing hippocampus.
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