ArticleFrontiers in aging neuroscience2010
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons.
Article in Frontiers in aging neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 76 citations in OpenAlex.
- Calorie Restriction Effects on Aging, Learning Performance, and Transcription in Aged Aplysia californica.Genes, brain, and behavior · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum.Infectious diseases of poverty · 2024Article
- Evolution of g-type lysozymes in metazoa: insights into immunity and digestive adaptations.Frontiers in cell and developmental biology · 2024Article
- RNA Isolation from Ctenophores.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The Expression of miRNAs Involved in Long-Term Memory Formation in the CNS of the MolluskInternational journal of molecular sciences · 2022Article
- An age-related decline in the cholinergic synaptic response may cause the firing pattern in the jaw-closing motor neurons, which resembles the aversive taste response in the feeding behavior of old Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.Journal of morphology · 2022Article
- Genome-Wide Analyses of Heat Shock Protein Superfamily Provide New Insights on Adaptation to Sulfide-Rich Environments inInternational journal of molecular sciences · 2022Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution.Analytical chemistry · 2021Article
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- Characterization of Neuronal RNA Modifications during Non-associative Learning inACS central science · 2021Article
- ATP signaling in the integrative neural center of Aplysia californica.Scientific reports · 2021Article
- Multiple Origins of Neurons From Secretory Cells.Frontiers in cell and developmental biology · 2021Article
- Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.PloS one · 2021Article
- The unlimited potential of the great pond snail,eLife · 2020Article
- Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases.Invertebrate neuroscience : IN · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aplysia californica is a powerful experimental system to study the entire scope of genomic and epigenomic regulation at the resolution of single functionally characterized neurons and is an emerging model in the neurobiology of aging. First, we have identified and cloned a number of evolutionarily conserved genes that are age-related, including components of apoptosis and chromatin remodeling. Second, we performed gene expression profiling of different identified cholinergic neurons between young and aged animals. Our initial analysis indicates that two cholinergic neurons (R2 and LPl1) revealed highly differential genome-wide changes following aging suggesting that on the molecular scale different neurons indeed age differently. Each of the neurons tested has a unique subset of genes differentially expressed in older animals, and the majority of differently expressed genes (including those related to apoptosis and Alzheimer's disease) are found in aging neurons of one but not another type. The performed analysis allows us to implicate (i) cell specific changes in histones, (ii) DNA methylation and (iii) regional relocation of RNAs as key processes underlying age-related changes in neuronal functions and synaptic plasticity. These mechanisms can fine-tune the dynamics of long-term chromatin remodeling, or control weakening and the loss of synaptic connections in aging. At the same time our genomic tests revealed evolutionarily conserved gene clusters associated with aging (e.g., apoptosis-, telomere- and redox-dependent processes, insulin and estrogen signaling and water channels).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.