ArticleFrontiers in neural circuits2010
Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.
Article in Frontiers in neural circuits, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
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- Automating literature screening and curation with applications to computational neuroscience.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Reproducibility of biophysical in silico neuron states and spikes from event-based partial histories.PLoS computational biology · 2023Article
- Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts.Neuroinformatics · 2023Article
- Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation.Brain, behavior, and immunity · 2023Article
- Altered synaptic plasticity at hippocampal CA1-CA3 synapses in Alzheimer's disease: integration of amyloid precursor protein intracellular domain and amyloid beta effects into computational models.Frontiers in computational neuroscience · 2023Article
- Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain.Frontiers in neuroinformatics · 2021Review
- A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients.Biological psychiatry · 2020Article
- The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging.Frontiers in aging neuroscience · 2020Article
- Automated Metadata Suggestion During Repository Submission.Neuroinformatics · 2019Article
- Transient Potassium Channels: Therapeutic Targets for Brain Disorders.Frontiers in cellular neuroscience · 2019Review
- The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow.PLoS computational biology · 2018Article
- What can computational modeling offer for studying the CaNeural regeneration research · 2018Review
- Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience.Journal of computational neuroscience · 2017Review
- Capturing intracellular CaDrug discovery today. Disease models · 2016Article
- ModelView for ModelDB: Online Presentation of Model Structure.Neuroinformatics · 2015Article
- The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels.Frontiers in cellular neuroscience · 2015Article
- Article
- Frequency dependence of CA3 spike phase response arising from h-current properties.Frontiers in cellular neuroscience · 2013Article
- Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses.Frontiers in computational neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The integrative properties of cortical pyramidal dendrites are essential to the neural basis of cognitive function, but the impact of amyloid beta protein (abeta) on these properties in early Alzheimer's is poorly understood. In animal models, electrophysiological studies of proximal dendrites have shown that abeta induces hyperexcitability by blocking A-type K+ currents (I(A)), disrupting signal integration. The present study uses a computational approach to analyze the hyperexcitability induced in distal dendrites beyond the experimental recording sites. The results show that back-propagating action potentials in the dendrites induce hyperexcitability and excessive calcium concentrations not only in the main apical trunk of pyramidal cell dendrites, but also in their oblique dendrites. Evidence is provided that these thin branches are particularly sensitive to local reductions in I(A). The results suggest the hypothesis that the oblique branches may be most vulnerable to disruptions of I(A) by early exposure to abeta, and point the way to further experimental analysis of these actions as factors in the neural basis of the early decline of cognitive function in Alzheimer's.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.