ArticleAmerican journal of hypertension2011
Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats.
Article in American journal of hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Growth Restriction in Preeclampsia: Lessons from Animal Models.Current opinion in physiology · 2023Article
- Pathophysiology of Preeclampsia and L-Arginine/L-Citrulline Supplementation as a Potential Strategy to Improve Birth Outcomes.Advances in experimental medicine and biology · 2023Review
- Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022Review
- Oxidative and Inflammatory Imbalance in Placenta and Kidney of sFlt1-Induced Early-Onset Preeclampsia Rat Model.Antioxidants (Basel, Switzerland) · 2022Article
- Animal Models of Preeclampsia: Mechanistic Insights and Promising Therapeutics.Endocrinology · 2022Review
- Article
- Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications.Antioxidants (Basel, Switzerland) · 2021Review
- Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia.International journal of molecular sciences · 2020Article
- Preeclampsia link to gestational hypoxia.Journal of developmental origins of health and disease · 2019Review
- Identifying immune mechanisms mediating the hypertension during preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.Hypertension (Dallas, Tex. : 1979) · 2014Article
- TH17- and IL-17- mediated autoantibodies and placental oxidative stress play a role in the pathophysiology of pre-eclampsia.Minerva ginecologica · 2014Review
- Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia.Frontiers in pharmacology · 2014Article
- Heme oxygenase inhibition increases blood pressure in pregnant rats.American journal of hypertension · 2013Article
- Effects of shear stresses and antioxidant concentrations on the production of reactive oxygen species in lung cancer cells.Biomicrofluidics · 2013Article
- Mechanisms and management of hypertension in pregnant women.Current hypertension reports · 2011Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPreeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat.
methodsMean arterial pressure (MAP), and plasma sFlt-1 and tissue ROS levels were measured in the following groups: (i) pregnant controls; (ii) sFlt-1-treated pregnant rats; (iii) Tempol-treated pregnant rats; (iv) sFlt-1- and Tempol-treated pregnant rats.
resultsMAP increased from 104 ± 2 mm Hg in pregnant control rats to 118 ± 3 mm Hg (P = 0.002) in sFlt-1-infused rats. Basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated levels of tissue ROS were increased in response to excess sFlt-1 during pregnancy. Pretreatment with Tempol attenuated oxidative stress and hypertension in response to sFlt-1.
conclusionsROS play an important role in mediating hypertension in response to chronic sFlt-1 excess during pregnancy.
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