ArticleCell cycle (Georgetown, Tex.)2010
Clusters, factories and domains: The complex structure of S-phase comes into focus.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- ATXN3 controls DNA replication and transcription by regulating chromatin structure.Nucleic acids research · 2023Article
- Modeling the Dynamics of Eukaryotic DNA Synthesis in Remembrance of Tunde Ogunnaike.Industrial & engineering chemistry research · 2023Article
- The location and development of Replicon Cluster Domains in early replicating DNA.Wellcome open research · 2023Article
- Article
- Outer kinetochore protein Dam1 promotes centromere clustering in parallel with Slk19 in budding yeast.Chromosoma · 2019Article
- Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.Cell reports · 2017Article
- WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.Scientific reports · 2017Article
- Dynamics of plant DNA replication based on PCNA visualization.Scientific reports · 2016Article
- New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress.Nucleic acids research · 2016Article
- A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.Nature structural & molecular biology · 2015Article
- Activation of new replication foci under conditions of replication stress.Cell cycle (Georgetown, Tex.) · 2015Article
- Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization.Journal of molecular biology · 2014Review
- The contribution of dormant origins to genome stability: from cell biology to human genetics.DNA repair · 2014Review
- Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Open biology · 2014Article
- Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells.Oncoscience · 2014Article
- Replicating damaged DNA in eukaryotes.Cold Spring Harbor perspectives in biology · 2013Review
- Stochastic association of neighboring replicons creates replication factories in budding yeast.The Journal of cell biology · 2013Article
- HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.Neoplasia (New York, N.Y.) · 2013Article
- Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.Chromosoma · 2013Article
- Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis.Chromosoma · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
During S-phase of the cell cycle, chromosomal DNA is replicated according to a complex replication timing program, with megabase-sized domains replicating at different times. DNA fibre analysis reveals that clusters of adjacent replication origins fire near-synchronously. Analysis of replicating cells by light microscopy shows that DNA synthesis occurs in discrete foci or factories. The relationship between timing domains, origin clusters and replication foci is currently unclear. Recent work, using a hybrid Xenopus/hamster replication system, has shown that when CDK levels are manipulated during S-phase the activation of replication factories can be uncoupled from progression through the replication timing program. Here, we use data from this hybrid system to investigate potential relationships between timing domains, origin clusters and replication foci. We suggest that each timing domain typically comprises several replicon clusters, which are usually processed sequentially by replication factories. We discuss how replication might be regulated at different levels to create this complex organisation and the potential involvement of CDKs in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.