ArticleStroke2010
Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses.
Article in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.Human brain mapping · 2016Pooled it
- The genetic and environmental etiology of novel frequency-driven regional parcellations of abnormal white matter.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.Communications biology · 2024Article
- Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.Human brain mapping · 2023Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- Cardiovascular risks impact human brainProceedings of the National Academy of Sciences of the United States of America · 2019Article
- White matter and hypoxic hypobaria in humans.Human brain mapping · 2019Article
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.Obesity (Silver Spring, Md.) · 2017Article
- Reproducibility of quantitative structural and physiological MRI measurements.Brain and behavior · 2017Article
- Epigenetic Age Acceleration Assessed with Human White-Matter Images.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.Scientific reports · 2016Article
- Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure.NeuroImage. Clinical · 2016Article
- Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
- Integrating multiple genomic data: sparse representation based biomarker selection for blood pressure.BMC proceedings · 2016Article
- Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.Human brain mapping · 2014Article
- Accelerated white matter aging in schizophrenia: role of white matter blood perfusion.Neurobiology of aging · 2014Article
- Multimodal white matter imaging to investigate reduced fractional anisotropy and its age-related decline in schizophrenia.Psychiatry research · 2014Article
- Lower neurocognitive function in U-2 pilots: Relationship to white matter hyperintensities.Neurology · 2014Article
- Different locations but common associations in subcortical hypodensities of presumed vascular origin: cross-sectional study on clinical and neurosonologic correlates.BMC neurology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe volume of T2-hyperintense white matter (HWM) is an important neuroimaging marker of cerebral integrity with a demonstrated high heritability. Pathophysiology studies have shown that the regional, ependymal, and subcortical HWM lesions are associated with elevated arterial pulse pressure and arterial blood pressure (BP), respectively. We performed bivariate, whole-genome linkage analyses for HWM volumes and BP measurements to identify chromosomal regions that contribute jointly to both traits in a population of healthy Mexican Americans. Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements.
methodsBP measurements and volumes of whole-brain (WB), subcortical, and ependymal HWM lesions, measured from high-resolution (1 mm(3)) 3-dimensional fluid-attenuated inversion recovery images, served as focal quantitative phenotypes. Data were collected from 357 (218 females; mean age=47.9±13.2 years) members of large extended families who participated in the San Antonio Family Heart Study.
resultsBivariate genomewide linkage analyses localized a significant quantitative trait locus influencing WB and regional (ependymal) HWM volumes and pulse pressure and systolic BP to chromosomal location 1q24 between markers D1S196 and D1S1619. Several other chromosomal regions (1q42, 10q24-q26, and 15q26) exhibited suggestive linkages. The results of the post hoc analyses that excluded 55 subjects taking antihypertensive medication showed no substantive differences from the results obtained in the full cohort.
conclusionsThis study confirms several previously observed quantitative trait loci influencing BP and cerebral integrity and identifies a novel significant quantitative trait locus at chromosome 1q24. The genetic results strongly support a role for pleiotropically acting genes jointly influencing BP and cerebral white matter integrity.
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