ArticlePlant physiology2010
Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- Review
- Phytochemical Composition of Clonally PropagatedMolecules (Basel, Switzerland) · 2026Article
- Targeted Gene Modification ofInternational journal of molecular sciences · 2026Article
- Article
- Transcriptome repository of North-Western Himalayan endangered medicinal herbs: a paramount approach illuminating molecular perspective of phytoactive molecules and secondary metabolism.Molecular genetics and genomics : MGG · 2021Review
- Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua.Journal of experimental botany · 2019Article
- The SPB-Box Transcription FactorFrontiers in plant science · 2019Article
- Cloning and characterization of enoate reductase with high β-ionone to dihydro-β-ionone bioconversion productivity.BMC biotechnology · 2018Article
- Biotechnological approaches for artemisinin production in Artemisia.World journal of microbiology & biotechnology · 2018Review
- Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes ofFrontiers in plant science · 2018Article
- New insights into artemisinin regulation.Plant signaling & behavior · 2017Review
- Article
- Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence.Planta · 2016Article
- Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites.Journal of natural medicines · 2016Review
- Expression of β-glucosidase increases trichome density and artemisinin content in transgenic Artemisia annua plants.Plant biotechnology journal · 2016Article
- Overexpression of AaWRKY1 Leads to an Enhanced Content of Artemisinin in Artemisia annua.BioMed research international · 2016Article
- Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production.Protoplasma · 2016Review
- Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production.Frontiers in plant science · 2016Review
- Transgenic approach to increase artemisinin content in Artemisia annua L.Plant cell reports · 2014Review
- 21st century natural product research and drug development and traditional medicines.Natural product reports · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The relationship between the transition to budding and flowering in Artemisia annua and the production of the antimalarial sesquiterpene, artemisinin (AN), the dynamics of artemisinic metabolite changes, AN-related transcriptional changes, and plant and trichome developmental changes were measured. Maximum production of AN occurs during full flower stage within floral tissues, but that changes in the leafy bracts and nonbolt leaves as the plant shifts from budding to full flower. Expression levels of early pathway genes known to be involved in isopentenyl diphosphate and farnesyl diphosphate biosynthesis leading to AN were not immediately positively correlated with either AN or its precursors. However, we found that the later AN pathway genes, amorpha-4,11-diene synthase (ADS) and the cytochrome P450, CYP71AV1 (CYP), were more highly correlated with AN's immediate precursor, dihydroartemisinic acid, within all leaf tissues tested. In addition, leaf trichome formation throughout the developmental phases of the plant also appears to be more complex than originally thought. Trichome changes correlated closely with the levels of AN but not its precursors. Differences were observed in trichome densities that are dependent both on developmental stage (vegetative, budding, and flowering) and on position (upper and lower leaf tissue). AN levels declined significantly as plants matured, as did ADS and CYP transcripts. Spraying leaves with AN or artemisinic acid inhibited CYP transcription; artemisinic acid also inhibited ADS transcription. These data allow us to present a novel model for the differential control of AN biosynthesis as it relates to developmental stage and trichome maturation and collapse.
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Registered trials
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