ArticleThe American journal of pathology2010
Assessing pulmonary pathology by detailed examination of respiratory function.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Optimization of intranasal bleomycin dose for effective pulmonary fibrosis induction in mice with minimal animal distress.BMC pulmonary medicine · 2025Article
- OC-STAMP is a potential biomarker and therapeutic target for Silicosis: an exploratory investigation.Journal of translational medicine · 2025Article
- Traditional pediatric massage enhanced the skeletal muscle mass in OVA-exposed adolescent rats via regulating SCFAs-FFAR2-IGF-1/AKT pathway.Frontiers in microbiology · 2024Article
- Feasibility of applying a noninvasive method for sleep monitoring based on mouse behaviors.Brain and behavior · 2023Article
- The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition.Molecules (Basel, Switzerland) · 2023Article
- A leak-free head-out plethysmography system to accurately assess lung function in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Measuring Breathing Patterns in Mice Using Whole-body Plethysmography.Bio-protocol · 2020Article
- The role of fuel type and combustion phase on the toxicity of biomass smoke following inhalation exposure in mice.Archives of toxicology · 2019Article
- Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models.The American journal of pathology · 2016Article
- Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice.Radiation research · 2016Article
- Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Chemokines mediate ethanol-induced exacerbations of murine cockroach allergen asthma.Clinical and experimental immunology · 2013Article
- Cecal ligation and puncture-induced murine sepsis does not cause lung injury.Critical care medicine · 2013Article
- A2B adenosine receptor expression by myeloid cells is proinflammatory in murine allergic-airway inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice.The American journal of pathology · 2012Article
- Cockroach allergens induce biphasic asthma-like pulmonary inflammation in outbred mice.The Journal of asthma : official journal of the Association for the Care of Asthma · 2012Article
- Pulmonary endotoxin tolerance protects against cockroach allergen-induced asthma-like inflammation in a mouse model.International archives of allergy and immunology · 2012Article
- Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines.The American journal of pathology · 2011Article
- Herbal medicine treatment reduces inflammation in a murine model of cockroach allergen-induced asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pulmonary inflammation causes multiple alterations within the lung, including mucus production, recruitment of inflammatory cells, and airway hyperreactivity (AHR). Measurement of AHR by direct, invasive means (eg, mechanical ventilation) or noninvasive techniques, like whole body plethysmography (WBP), assesses the severity of pulmonary inflammation in animal models of inflammatory lung disease. Direct measurement of AHR is acknowledged as the most accurate method for assessing airway mechanics, but analysis of all data obtained from WBP may offer insights into which inflammatory aspects of the lung are altered along with AHR. Using WBP, we compared the respiratory parameters of two groups of mice sensitized with cockroach allergen. One group was treated with dexamethasone (Dex) before final challenge (Dex-Asthma), while the other group received vehicle treatment (Asthma). Respiratory parameters from plethysmography revealed that Dex-Asthma mice compensated to maintain high minute ventilation, whereas Asthma mice showed significant impairment in minute ventilation despite increased peak expiratory flow (103 ± 5 ml/min vs. 69 ± 70 ml/min). The WBP data suggest that enhanced air exchange in the Dex-Asthma mice results from significant decreases in airway mucus production. Additional studies with quantitative morphometry of histological sections confirmed that Dex reduced airway mucus. In conclusion, a detailed examination of WBP parameters can accurately assess the respiratory health of mice and will help direct additional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.