Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2010
Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 74 citations in OpenAlex.
- New Zealand blackcurrant extract has no effect on physiological and cardiovascular responses during low-intensity sustained intermittent isometric contractions in men.European journal of applied physiology · 2026Trial
- The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness.Physiological reports · 2025Trial
- Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post-traumatic stress disorder.Experimental physiology · 2024Trial
- Impaired modulation of postjunctional αThe Journal of physiology · 2018Trial
- Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Altered neurovascular control of the resting circulation in human metabolic syndrome.The Journal of physiology · 2012Trial
- Skeletal muscle microvascular and respiratory responses to exercise in healthy and T2D adults: agreement and reproducibility study of NIRS technologies.European journal of applied physiology · 2026Article
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Does the Menstrual Phase Matter in Vascular Endothelial Responses to Acute Exercise? A Narrative Review of the Literature.Sports (Basel, Switzerland) · 2025Review
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Blunted brachial blood flow velocity response to acute mental stress in PTSD females.Physiological reports · 2024Article
- α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- Sex differences in muscle contraction-induced limb blood flow limitations.European journal of applied physiology · 2024Article
- Adjusting for muscle strength and body size attenuates sex differences in the exercise pressor reflex in young adults.American journal of physiology. Heart and circulatory physiology · 2023Article
- Altered central and peripheral haemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2.Experimental physiology · 2022Article
- Men exhibit faster skeletal muscle tissue desaturation than women before and after a fatiguing handgrip.European journal of applied physiology · 2021Article
- Influence of muscular contraction on vascular conductance during exercise above versus below critical power.Respiratory physiology & neurobiology · 2021Article
- Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.Experimental physiology · 2021Article
- Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Sex-related differences in rapid-onset vasodilation: impact of aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sex differences exist in autonomic control of the cardiovascular system. This study was designed to directly test sex or female menstrual phase-related differences in α-adrenergic control of blood flow during exercise. We hypothesized that women would exhibit reduced α-adrenergic vasoconstriction compared with men during exercise; in addition, women would constrict less during the early luteal than the early follicular phase of the female menses. Young men (n = 10) were studied once and women (n = 9) studied twice, once during the early follicular phase and once during the early luteal phase of female menses. We measured forearm blood flow (FBF; Doppler ultrasound of the brachial artery) during rest and steady-state dynamic exercise (15 and 30% of maximal voluntary contraction, 20 contractions/min). A brachial artery catheter was inserted for the local administration of α-adrenergic agonists [phenylephrine (PE; α(1)) or clonidine (CL; α(2))]. Blood flow responses to exercise [forearm vascular conductance (FVC)] were similar between all groups. At rest, infusion of PE or CL decreased FVC in all groups (40-60% reduction). Vasoconstriction to PE was abolished in all groups at 15 and 30% exercise intensity. Vasoconstriction to CL was reduced at 15% and abolished at 30% intensity in all groups; women had less CL-induced constriction during the early luteal than early follicular phase (P < 0.017, 15% intensity). These results indicate that vasodilator responses to forearm exercise are comparable between men and women and are achieved through similar paths of α-adrenergic vascular control at moderate intensities; this control may differ at low intensities specific to the female menstrual phase.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.