ArticleMolecular cancer research : MCR2010
Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment.
Article in Molecular cancer research : MCR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Endothelial dysfunction determines vascular mechanisms of metastatic progression in breast cancer.Discover oncology · 2026Review
- Premetastatic niche mechanics and organotropism in breast cancer.npj biological physics and mechanics · 2025Review
- Mechanisms of Organ-Specific Metastasis of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2023Review
- Thorny ground, rocky soil: Tissue-specific mechanisms of tumor dormancy and relapse.Seminars in cancer biology · 2022Review
- Autophagy and Hepatic Tumor Microenvironment Associated Dormancy.Journal of gastrointestinal cancer · 2021Review
- Is ThereCancers · 2021Article
- The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile.Science advances · 2021Article
- Organotropism: new insights into molecular mechanisms of breast cancer metastasis.NPJ precision oncology · 2018Review
- The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Intravital imaging of the effects of 5-fluorouracil on the murine liver microenvironment using 2-photon laser scanning microscopy.Oncology letters · 2016Article
- Cancer and the metastatic substrate.Ecancermedicalscience · 2016Review
- Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.Oncotarget · 2015Article
- RhoC and ROCKs regulate cancer cell interactions with endothelial cells.Molecular oncology · 2015Article
- Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver.Molecular cancer · 2015Article
- Mechanisms involved in breast cancer liver metastasis.Journal of translational medicine · 2015Review
- Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2014Article
- Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.The Journal of cell biology · 2012Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
To examine the interplay between tumor cells and the microenvironment during early breast cancer metastasis, we developed a technique for ex vivo imaging of murine tissue explants using two-photon microscopy. Cancer cells in the liver and the lung were compared by imaging both organs at specific time points after the injection of the same polyomavirus middle T-initiated murine mammary tumor cell line. Extravasation was greatly reduced in the lung compared with the liver, with 56% of tumor cells in the liver having extravasated by 24 hours, compared with only 22% of tumor cells in the lung that have extravasated. In the liver, imaged cells continually transitioned from an intravascular location to an extravascular site, whereas in the lung, extravasation rates slowed after 6 hours. Within the liver microenvironment, the average size of the imaged micrometastatic lesions increased 4-fold between days 5 and 12. Histologic analysis of these lesions determined that by day 12, the micrometastases were heterogeneous, consisting of both tumor cells and von Willebrand factor-positive endothelial cells. Further analysis with intravenously administered lectin indicated that vessels within the micrometastatic tumor foci were patent by day 12. These data present the use of two-photon microscopy to directly compare extravasation times in metastatic sites using the same tumor cell line and highlight the differences in early events and metastatic patterns between two important secondary sites of breast cancer progression with implications for future therapy.
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