ArticleMicrobiology (Reading, England)2010
Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans.
Article in Microbiology (Reading, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Investigating the origin of subtelomeric and centromeric AT-rich elements in Aspergillus flavus.PloS one · 2023Article
- Article
- The Putative Histone Methyltransferase DOT1 Regulates Aflatoxin and Pathogenicity Attributes in Aspergillus flavus.Toxins · 2017Article
- The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism.Fungal genetics and biology : FG & B · 2017Article
- Characterization of the Far Transcription Factor Family in Aspergillus flavus.G3 (Bethesda, Md.) · 2016Article
- The Different Roles ofFrontiers in microbiology · 2016Article
- Expression and chromatin structures of cellulolytic enzyme gene regulated by heterochromatin protein 1.Biotechnology for biofuels · 2016Article
- Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation.ACS chemical biology · 2015Article
- Article
- A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.PloS one · 2014Article
- The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters.PLoS genetics · 2013Article
- A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine.The Journal of biological chemistry · 2013Article
- Article
- Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans.PLoS genetics · 2013Article
- Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production.Molecular microbiology · 2012Article
- Identification of a gene involved in the synthesis of a dipeptidyl peptidase IV inhibitor in Aspergillus oryzae.Applied and environmental microbiology · 2012Article
- The chromatin code of fungal secondary metabolite gene clusters.Applied microbiology and biotechnology · 2012Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Gene-silencing mechanisms are being shown to be associated with an increasing number of fungal developmental processes. Telomere position effect (TPE) is a eukaryotic phenomenon resulting in gene repression in areas immediately adjacent to telomere caps. Here, TPE is shown to regulate expression of transgenes on the left arm of chromosome III and the right arm of chromosome VI in Aspergillus nidulans. Phenotypes found to be associated with transgene repression included reduction in radial growth and the absence of sexual spores; however, these pleiotropic phenotypes were remedied when cultures were grown on media with appropriate supplementation. Simple radial growth and ascosporogenesis assays provided insights into the mechanism of TPE, including a means to determine its extent. These experiments revealed that the KU70 homologue (NkuA) and the heterochromatin-associated proteins HepA, ClrD and HdaA were partially required for transgene silencing. This study indicates that TPE extends at least 30 kb on chromosome III, suggesting that this phenomenon may be important for gene regulation in subtelomeric regions of A. nidulans.
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