ArticleBMC genomics2010
DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Evidence for Paternal Mitochondrial DNA Leakage in Diploid Hybrid Fish Lineages.Animals : an open access journal from MDPI · 2026Article
- Maternal and fetal mitochondrial gene dysregulation in hypertensive disorders of pregnancy.Physiological genomics · 2023Article
- Mitochondrial biology and prostate cancer ethnic disparity.Carcinogenesis · 2018Review
- Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder.Translational psychiatry · 2017Article
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development.The Journal of reproduction and development · 2017Article
- The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.Reproductive biology and endocrinology : RB&E · 2014Review
- Intraclonal recovery of 'slow clones'-a manifestation of genomic instability: are mitochondria the key to an explanation?Radiation and environmental biophysics · 2014Review
- The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Human genetics · 2014Review
- Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations.Frontiers in genetics · 2014Review
- The mitochondrial epigenome: a role in Alzheimer's disease?Epigenomics · 2014Review
- Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.The Journal of biological chemistry · 2013Article
- The role of mitochondria from mature oocyte to viable blastocyst.Obstetrics and gynecology international · 2013Article
- Mitochondrial regulation of epigenetics and its role in human diseases.Epigenetics · 2012Review
- Mitochondrial DNA: A Blind Spot in Neuroepigenetics.Biomolecular concepts · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitochondria are semi-autonomous, semi-self-replicating organelles harboring their own DNA (mitochondrial DNA, mtDNA), and their dysregulation is involved in the development of various diseases. While mtDNA does not generally undergo epigenetic modifications, almost all mitochondrial proteins are encoded by nuclear DNA. However, the epigenetic regulation of nuclear-encoded mitochondrial genes (nuclear mt genes) has not been comprehensively analyzed.
resultsWe analyzed the DNA methylation status of 899 nuclear mt genes in the liver, brain, and heart tissues of mouse, and identified 636 nuclear mt genes carrying tissue-dependent and differentially methylated regions (T-DMRs). These nuclear mt genes are involved in various mitochondrial functions and they also include genes related to human diseases. T-DMRs regulate the expression of nuclear mt genes. Nuclear mt genes with tissue-specific hypomethylated T-DMRs were characterized by enrichment of the target genes of specific transcription factors such as FOXA2 in the liver, and CEBPA and STAT1 in the brain.
conclusionsA substantial proportion of nuclear mt genes contained T-DMRs, and the DNA methylation status of numerous T-DMRs should underlie tissue-dependent mitochondrial functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.