ArticleNeurogastroenterology and motility2011
Changes in interstitial cells of cajal with age in the human stomach and colon.
Article in Neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- The Clinical Relevance of the Rectosigmoid Brake in Surgical Disorders and Therapies: A Systematic Review of Colonic Manometry Studies.Neurogastroenterology and motility · 2026Pooled it
- Spectrum of Interstitial Cell of Cajal Deficits in Chronic Gastroduodenal Disorders: Systematic Review and Meta-Analysis.The American journal of gastroenterology · 2026Pooled it
- Variations in the Density and Distribution of Cajal Like Cells Associated With the Pathogenesis of Ureteropelvic Junction Obstruction: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms.World journal of gastroenterology · 2017Pooled it
- Maladaptive Piezo1 Mechanotransduction Drives Smooth Muscle Aging in the Gut.bioRxiv : the preprint server for biology · 2026Article
- Comparative analysis of bowel preparation quality for colonoscopy: a survey of outpatients and inpatients.BMC gastroenterology · 2026Article
- Dolichocolon is common in pediatric gastroenterology patients with constipation and associated complaints.Journal of pediatric gastroenterology and nutrition · 2026Article
- Nausea and Gastric Myoelectrical Activity Are Influenced by Hormonal Contraception in Chronic Gastroduodenal Disorders.Clinical and translational gastroenterology · 2025Article
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- miR-10a-5p and miR-10b-5p restore colonic motility in aged mice.World journal of gastroenterology · 2025Article
- Overall and Regional Colonic Transit Abnormalities in Elderly Patients with Constipation.Digestive diseases and sciences · 2025Article
- Cellular and molecular mechanisms underlying aging-related gastric neuromuscular dysfunction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- Colonic Gastrointestinal Stromal Tumors Demonstrate Unique Biological Characteristics: A Retrospective, Propensity Score-Matched Cohort Study Pooling Multicenter and Literature-Derived Individual Patient Data.Clinical Medicine Insights. Oncology · 2025Article
- Gastrointestinal Motility Function and Dysfunction in the Elderly Patient: What Are the Effects of Aging?Visceral medicine · 2024Review
- Effect of menstrual cycle and menopause on human gastric electrophysiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- CaPhysiological reviews · 2024Review
- Improving Gastric Motility in Aging Through EZH2 Inhibition and Preservation of Interstitial Cells of Cajal.Cellular and molecular gastroenterology and hepatology · 2024Article
- Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats.Neurogastroenterology and motility · 2023Article
- Review
- Interstitial cells of Cajal: clinical relevance in pediatric gastrointestinal motility disorders.Pediatric surgery international · 2023Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAging produces inevitable changes in the function of most organs including the gastrointestinal tract. Together with enteric nerves and smooth muscle cells, interstitial cells of Cajal (ICC) play a key role in the control of gastrointestinal motility, yet little is known about the effect of aging on ICC. The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon.
methodsGastric and colonic tissues from patients aged 25-70 and 36-92 years old, respectively, and with no co-existent motility disorders were immunolabeled with an anti-Kit antibody and ICC were counted in the circular muscle and myenteric regions. Network volumes were measured using 3D reconstructions of confocal stacks. The effects of aging were determined by testing for linear trends using regression analysis. KEY
resultsIn both stomach and colon, the number of ICC bodies and volume significantly decreased with age at a rate of 13% per decade. ICC size was only affected in the myenteric plexus in the colon. The changes associated with age were not differentially affected by sex or colonic region. CONCLUSIONS & INFERENCES: The number and volume of ICC networks in the normal human stomach and colon decline with age. This decrease in ICC likely reduces the functional capacity of the gastrointestinal motor apparatus, may contribute to changes in gastrointestinal motility with aging and may influence intestinal responses to insults such as disease, operative interventions and medications in older patients. Tissue specimens must be carefully age-matched when studying ICC in disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.