ArticleJournal of the American Geriatrics Society2010
Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging.
Article in Journal of the American Geriatrics Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03800342 (Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals), which is not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Effects of Exercise Training on the Metabolic Cost of Walking in Health and Disease: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Effects of experimentally induced fatigue on healthy older adults' gait: A systematic review.PloS one · 2019Pooled it
- Systematic review and meta-analysis of skeletal muscle fatigue in old age.Medicine and science in sports and exercise · 2011Pooled it
- Consequences of lower extremity and trunk muscle fatigue on balance and functional tasks in older people: a systematic literature review.BMC geriatrics · 2010Pooled it
- Effects of an individualised exercise programme plus Behavioural Change Enhancement (BCE) strategies for managing fatigue in frail older adults: a cluster randomised controlled trial.BMC geriatrics · 2023Trial
- Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Post-stroke fatigue as an indicator of underlying bioenergetics alterations.Journal of bioenergetics and biomembranes · 2019Trial
- Docetaxel-related fatigue in men with metastatic prostate cancer: a descriptive analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Trial
- Longitudinal relationships between subjective fatigue, cognitive function, and everyday functioning in old age.International psychogeriatrics · 2013Trial
- A phenomenological study of fatigue experience in community-dwelling older adults.BMC geriatrics · 2026Article
- The relationship between sleep and fatigue within community-residing older individuals aged 60 years or above in regional China.Frontiers in public health · 2026Article
- Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue.Frontiers in neuroscience · 2025Article
- Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging.Aging cell · 2024Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging.Journal of the American Geriatrics Society · 2024Article
- Combined non-targeted and targeted metabolomics reveals the mechanism of delaying aging of Ginseng fibrous root.Frontiers in pharmacology · 2024Article
- Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Circadian disturbances and frailty risk in older adults.Nature communications · 2023Article
- Fatigue in Alzheimer's disease: biological basis and clinical management-a narrative review.Aging clinical and experimental research · 2023Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The American Geriatrics Society, with support from the National Institute on Aging and the John A. Hartford Foundation, held its fifth Bedside-to-Bench research conference, "Idiopathic Fatigue and Aging," to provide participants with opportunities to learn about cutting-edge research developments, draft recommendations for future research, and network with colleagues and leaders in the field. Fatigue is a symptom that older persons, especially by those with chronic diseases, frequently experience. Definitions and prevalence of fatigue may vary across studies, across diseases, and even between investigators and patients. The focus of this review is on physical fatigue, recognizing that there are other related domains of fatigue (such as cognitive fatigue). Many definitions of fatigue involve a sensation of "low" energy, suggesting that fatigue could be a disorder of energy balance. Poor energy utilization efficiency has not been considered in previous studies but is likely to be one of the most important determinants of fatigue in older individuals. Relationships between activity level, capacity for activity, a tolerable rate of activity, and a tolerable fatigue threshold or ceiling underlie a notion of fatiguability. Mechanisms probably contributing to fatigue in older adults include decline in mitochondrial function, alterations in brain neurotransmitters, oxidative stress, and inflammation. The relationships between muscle function and fatigue are complex. A number of diseases (such as cancer) are known to cause fatigue and may serve as models for how underlying impaired physiological processes contribute to fatigue, particularly those in which energy utilization may be an important factor. A further understanding of fatigue will require two key strategies: to develop and refine fatigue definitions and measurement tools and to explore underlying mechanisms using animal and human models.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.