ArticleJournal of medical primatology2011
Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation.
Article in Journal of medical primatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Multiplex PCR System for the Diagnosis of Plague.Current molecular medicine · 2025Review
- Non-human primate models of human respiratory infections.Molecular immunology · 2021Review
- Present and Future Perspectives on Therapeutic Options for Carbapenemase-ProducingMicroorganisms · 2021Review
- The African Green Monkey Model of Pneumonic Plague and US Food and Drug Administration Approval of Antimicrobials Under the Animal Rule.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Plazomicin: A Novel Aminoglycoside for the Treatment of Resistant Gram-Negative Bacterial Infections.Drugs · 2019Review
- Article
- Peripheral Blood Biomarkers of Disease Outcome in a Monkey Model of Rift Valley Fever Encephalitis.Journal of virology · 2018Article
- Considerations for Infectious Disease Research Studies Using Animals.Comparative medicine · 2017Review
- Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis.PloS one · 2016Article
- Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague.mBio · 2015Article
- A characterization of aerosolized Sudan virus infection in African green monkeys, cynomolgus macaques, and rhesus macaques.Viruses · 2012Article
- Article
- Levofloxacin cures experimental pneumonic plague in African green monkeys.PLoS neglected tropical diseases · 2011Article
- Model systems to study plague pathogenesis and develop new therapeutics.Frontiers in microbiology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrimary pneumonic plague is rare among humans, but treatment efficacy may be tested in appropriate animal models under the FDA 'Animal Rule'.
methodsTen African Green monkeys (AGMs) inhaled 44-255 LD(50) doses of aerosolized Yersinia pestis strain CO92. Continuous telemetry, arterial blood gases, chest radiography, blood culture, and clinical pathology monitored disease progression.
resultsOnset of fever, >39°C detected by continuous telemetry, 52-80 hours post-exposure was the first sign of systemic disease and provides a distinct signal for treatment initiation. Secondary endpoints of disease severity include tachypnea measured by telemetry, bacteremia, extent of pneumonia imaged by chest x-ray, and serum lactate dehydrogenase enzyme levels.
conclusionsInhaled Y. pestis in the AGM results in a rapidly progressive and uniformly fatal disease with fever and multifocal pneumonia, serving as a rigorous test model for antibiotic efficacy studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.