ArticleThe European journal of neuroscience2010
Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences.
Article in The European journal of neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
- Ameliorating Effect of Continuous Treatment With an Amorphous Formula of Curcumin on Maternal Imidacloprid Exposure-Induced Suppression of Hippocampal Neurogenesis in Rats.Environmental toxicology · 2026Article
- Hippocampal long-range GABAergic neurons target hippocampal-projecting cells of the supramammillary area.The Journal of physiology · 2026Article
- Caffeine reverses sleep deprivation-induced synaptic and social memory deficits via adenosine receptor modulation in the male mouse hippocampal CA2 region.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Perisomatic innervation on the semilunar granule cells and outer molecular layer granule cells of the dentate gyrus of the mouse.Frontiers in neuroanatomy · 2026Article
- Neural circuits and emotional processing in rapid eye movement sleep.Frontiers in psychiatry · 2025Review
- Article
- Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.Cell reports · 2024Article
- Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping.eLife · 2024Article
- Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons.Scientific reports · 2024Article
- Hypothalamic Supramammillary Control of Cognition and Motivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Intersectional mapping of multi-transmitter neurons and other cell types in the brain.Cell reports · 2022Article
- Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior.Nature neuroscience · 2022Article
- Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional Neuroanatomy of the Rat Nucleus Incertus-Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway.Frontiers in cellular neuroscience · 2022Article
- Hypothalamic Glutamate/GABA Cotransmission Modulates Hippocampal Circuits and Supports Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1.eLife · 2021Article
- GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep.Brain structure & function · 2020Article
- Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus.eLife · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore the control of hippocampal-dependent cognitive functions as well as emotional behavior. A major goal of this study was to characterize the neurotransmitter identity of the SuM-hippocampal pathways. Our findings demonstrate two distinct neurochemical pathways in rat. The first pathway originates from neurons in the lateral region of the SuM and innervates the supragranular layer of the dorsal dentate gyrus and, to a much lesser extent, the ventral dentate gyrus. This pathway displays a unique dual phenotype for GABAergic and glutamatergic neurotransmission. Axon terminals contain markers of GABAergic neurotransmission, including the synthesizing enzyme of GABA, glutamate decarboxylase 65, and the vesicular GABA transporter and also a marker of glutamatergic neurotransmission, the vesicular glutamate transporter 2. The second pathway originates from neurons in the most posterior and medial part of the SuM and innervates exclusively the inner molecular layer of the ventral dentate gyrus and the CA2/CA3a pyramidal cell layer of the hippocampus. The axon terminals from the medial part of the SuM contain the vesicular glutamate transporter 2 only. These data demonstrate for the first time the heterogeneity of the SuM-hippocampal pathways, not only from an anatomical but also a neurochemical point of view. These pathways, implicated in different neuronal networks, could modulate different hippocampal activities. They are likely to be involved differently in the regulation of hippocampal theta rhythm and associated cognitive functions as well as emotional behavior.
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Registered trials
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