ArticleAmerican journal of human biology : the official journal of the Human Biology Council
Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia.
Article in American journal of human biology : the official journal of the Human Biology Council. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
- The Effect of Helminth Infections and Their Treatment on Metabolic Outcomes: Results of a Cluster-Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Effect of cardiorespiratory fitness on acute inflammation induced increases in arterial stiffness in older adults.European journal of applied physiology · 2013Trial
- Ectopic adipose tissue in subsistence populations with minimal coronary disease, large left atria, and very low rates of atrial fibrillation.American journal of preventive cardiology · 2025Article
- Nonuniversality of inflammaging across human populations.Nature aging · 2025Article
- Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.Proceedings. Biological sciences · 2025Article
- Childhood skeletal lesions common in prehistory are present in living forager-farmers and predict adult markers of immune function.Science advances · 2025Article
- Modulation of cell-mediated immunity during pregnancy in wild bonobos.Biology letters · 2024Article
- Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention.Journal of clinical medicine · 2023Review
- Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
- Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort study.EClinicalMedicine · 2021Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Very Low Prevalence and Incidence of Atrial Fibrillation among Bolivian Forager-Farmers.Annals of global health · 2021Article
- Was facial width-to-height ratio subject to sexual selection pressures? A life course approach.PloS one · 2021Article
- C-reactive protein in traditional melanesians on Kitava.BMC cardiovascular disorders · 2020Article
- Microbiota assembly, structure, and dynamics among Tsimane horticulturalists of the Bolivian Amazon.Nature communications · 2020Observational
- Hematological parameters and hair mercury levels in adolescents from the Colombian Caribbean.Environmental science and pollution research international · 2020Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesLittle is known about blood cholesterol (blood-C) levels under conditions of infection and limited diet. This study examines blood-C and markers of infection and inflammation in the Tsimane of the Bolivian Amazon, indigenous forager farmers living in conditions that model preindustrial European populations by their short life expectancy, high load of infections and inflammation, and limited diets.
methodsWe use multivariate models to determine the relationships between lipid levels and markers of infection and inflammation. Adult Tsimane (N = 418, age 20-84) were characterized for blood lipids, cells, and inflammatory markers in relation to individual loads of parasites and village region.
resultsMost of the Tsimane (60%) carried at least one parasite species, averaging 1.3 species per person. Serum high-density lipoprotein cholesterol (HDL-C), total cholesterol (total-C), and low-density lipoprotein cholesterol (LDL-C) were below the U.S. norms and varied inversely with markers of infection and inflammation: C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), immunoglobulin (Ig) E and eosinophil count. Although no relationship of parasite load to blood-C was found, there was an association between anemia and parasite prevalence.
conclusionsWe conclude that the highly infected environment of the Tsimane is related to low levels of blood total-C, HDL-C, and LDL-C. This may suggest a potential reason why arterial disease is largely absent in the Tsimane.
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