ReviewMolecular carcinogenesis2010
The skinny on Slug.
Review in Molecular carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Upregulation of SLUG expression in canine mammary gland tumors and its prognostic significance.BMC veterinary research · 2023Article
- Epithelial-Mesenchymal Plasticity and Endothelial-Mesenchymal Transition in Cutaneous Wound Healing.Cold Spring Harbor perspectives in biology · 2023Review
- LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.The Journal of clinical investigation · 2023Article
- Evolutionary Origins of Metabolic Reprogramming in Cancer.International journal of molecular sciences · 2022Review
- The Contributions of Cancer-Testis and Developmental Genes to the Pathogenesis of Keratinocyte Carcinomas.Cancers · 2022Review
- Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.International journal of molecular sciences · 2021Article
- Linking EMT programmes to normal and neoplastic epithelial stem cells.Nature reviews. Cancer · 2021Review
- CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells.Science China. Life sciences · 2021Article
- Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process.Scientific reports · 2020Article
- Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.Molecular cancer research : MCR · 2020Article
- Molecular regulation of Snai2 in development and disease.Journal of cell science · 2019Review
- Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Intermediate cell states in epithelial-to-mesenchymal transition.Physical biology · 2019Review
- Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating CaTheranostics · 2019Article
- The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome.Clinical & experimental metastasis · 2018Review
- Epithelial-to-mesenchymal transition in cutaneous wound healing: Where we are and where we are heading.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- A Theoretical Model of the Wnt Signaling Pathway in the Epithelial Mesenchymal Transition.Theoretical biology & medical modelling · 2017Article
- Potential therapeutic targets of epithelial-mesenchymal transition in melanoma.Cancer letters · 2017Review
- Slug Modulates UV Radiation-Induced Cutaneous Inflammation by Regulating Epidermal Production of Proinflammatory Cytokines.The Journal of investigative dermatology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound healing, skin cancer, and sunburn. Slug is expressed in basal keratinocytes and hair follicles where it is important in maintaining epidermal homeostasis. Slug also helps coordinate the skin response to exogenous stimuli. Slug is rapidly induced by a variety of growth factors and injurious agents and Slug controls, directly or indirectly, a variety of keratinocyte responses, including changes in differentiation, adhesion, motility, and production of inflammatory mediators. Slug thus modulates the interactions of the keratinocyte with its environment and with surrounding cells. The function of Slug in the epidermis appears to be distinct from that of the closely related Snail transcription factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.