ReviewCurrent opinion in investigational drugs (London, England : 2000)2010
Brain dysfunction in the era of combination antiretroviral therapy: implications for the treatment of the aging population of HIV-infected individuals.
Review in Current opinion in investigational drugs (London, England : 2000), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05678660 (Study of Neurological Aging Among People Living With HIV), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Neurological Aging Among People Living With HIV (SNAP)
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Brief Report: Body Mass Index and Cognitive Function Among HIV-1-Infected Individuals in China, India, and Nigeria.Journal of acquired immune deficiency syndromes (1999) · 2019Pooled it
- HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.International journal of molecular sciences · 2026Review
- Synergistic effects of high early-life stress exposure and HIV infection on reaction time variability.Frontiers in psychology · 2023Article
- Effects of Early-Life Adversities on Neuropsychiatric and Executive Functions in HIV-Positive Adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- Microglia: The Real Foe in HIV-1-Associated Neurocognitive Disorders?Biomedicines · 2021Review
- New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System.Cells · 2019Review
- Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy.AIDS research and human retroviruses · 2019Article
- Effects of age, HIV, and HIV-associated clinical factors on neuropsychological functioning and brain regional volume in HIV+ patients on effective treatment.Journal of neurovirology · 2019Article
- Neural response to working memory demand predicts neurocognitive deficits in HIV.Journal of neurovirology · 2018Article
- Experiences of Discrimination Are Associated With Greater Resting Amygdala Activity and Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Early Life Stress-Related Elevations in Reaction Time Variability Are Associated with Brain Volume Reductions in HIV+ Adults.Frontiers in behavioral neuroscience · 2018Article
- Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer's Disease: an Emerging Issue in Geriatric NeuroHIV.Current HIV/AIDS reports · 2017Review
- High early life stress and aberrant amygdala activity: risk factors for elevated neuropsychiatric symptoms in HIV+ adults.Brain imaging and behavior · 2017Article
- Facial emotion recognition impairments are associated with brain volume abnormalities in individuals with HIV.Neuropsychologia · 2015Article
- Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice.Molecular neurodegeneration · 2014Article
- The role of tau protein in HIV-associated neurocognitive disorders.Molecular neurodegeneration · 2014Review
- Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals.Journal of neurovirology · 2014Article
- Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain.Nanomedicine : nanotechnology, biology, and medicine · 2014Article
- Exercise and the brain: a slap on the HAND.Journal of neurovirology · 2013Article
- Effects of HIV and early life stress on amygdala morphometry and neurocognitive function.Journal of the International Neuropsychological Society : JINS · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Improvements in the treatment of HIV infection and in the advancement of combination antiretroviral therapy (cART) have led to an increase in the number of individuals with HIV who are surviving to an older age. Preventing the development of neurocognitive abnormalities has become an increasingly important issue in this aging patient population, which is already at risk for cognitive impairment as a result of the neuropathological effects of HIV. cART has been critical in reducing the overall severity of HIV-associated neurocognitive disorders (HAND), but numerous challenges remain, as the prevalence of HAND continues to be high. There are several key areas in which treatment could be improved to reduce the incidence and severity of HAND. The use of well-tolerated cART medications that are able to penetrate the blood-brain barrier hold particular promise, as these agents may enable increased viral suppression in the parenchyma and may reduce neurocognitive dysfunction. In addition, the improved treatment of comorbid medical conditions that are common in patient populations with HIV (eg, HCV, liver failure and metabolic syndrome) is critical, as several of these conditions are known to have a significant effect on neural functions. Various research approaches indicate that the development of agents that control free radicals, neurotoxicity, proinflammatory processes and apoptosis may also have substantial potential in this field.
Indexed as
Identifiers
20721831PMC4021717W1632487469What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.