Evidence map›Paper›PMID 20721603›Full record

ReviewPharmaceutical research2011

Nanoparticle delivery systems in cancer vaccines.

Yogita Krishnamachari, Sean M Geary, Caitlin D Lemke, Aliasger K Salem

Abstract readReview
In one paragraph

Review in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Biomaterials Facilitating Dendritic Cell-Mediated Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  6. Virosome: An engineered virus for vaccine delivery.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Fabrication of subunit nanovaccines by physical interaction.Science China. Technological sciences · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Nanocarrier vaccines for SARS-CoV-2.Advanced drug delivery reviews · 2021
    Article
  19. CpG-Based Nanovaccines for Cancer Immunotherapy.International journal of nanomedicine · 2021
    Review
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yogita KrishnamachariDepartment of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA.
Sean M Geary
Caitlin D Lemke
Aliasger K Salem

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Chitosan-plasmid DNA nanoplexes and adenoviruses as prostate cancer vaccinesR21CA133456 · NCI · UNIVERSITY OF IOWA · PI SALEM, ALIASGER K · 2008 to 2009
$338k
Engineered Optimal Adjuvant and Antigen Release from Biodegradable NanoparticlesR21CA128414 · NCI · UNIVERSITY OF IOWA · PI SALEM, ALIASGER K · 2009 to 2010
$264k
NCI NIH HHS 1R21CA128414-01A2/UINCI NIH HHS 1R21CA13345-01NCI NIH HHS R21 CA128414NCI NIH HHS R21 CA133456NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Therapeutic strategies that involve the manipulation of the host's immune system are gaining momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively taken up by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy by initiating a strong immunostimulatory cascade that results in potent antigen-specific immune responses against the cancer. Such carrier systems offer versatility in that they can simultaneously co-deliver adjuvants with the antigens to enhance APC activation and maturation. Furthermore, modifying the surface properties of these nanocarriers affords active targeting properties to APCs and/or enhanced accumulation in solid tumors. Here, we review some recent advances in these colloidal and particulate nanoscale systems designed for cancer immunotherapy and the potential for these systems to translate into clinical cancer vaccines.

Indexed as

Adjuvants, ImmunologicAnimalsAntigen-Presenting CellsAntigens, NeoplasmCancer VaccinesDrug CarriersDrug Delivery SystemsHumansImmunotherapyMiceNanomedicineNanoparticlesNeoplasmsAdjuvants, ImmunologicAntigens, NeoplasmCancer VaccinesDrug Carriers

Identifiers

PMID20721603
PMCPMC3559243

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.