ArticleParasitology research2010
Modulation of immunity in mice with latent toxoplasmosis--the experimental support for the immunosuppression hypothesis of Toxoplasma-induced changes in reproduction of mice and humans.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients.BioMed research international · 2015Trial
- Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study.Scientific reports · 2026Article
- From Infection to Anxiety: A Sequential Model Linking Latent Toxoplasmosis to Psychological Distress via Health and Stress.Scandinavian journal of psychology · 2026Article
- Special Issue: Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap.Folia parasitologica · 2026Article
- The Impact of Chronic Toxoplasmosis on the Gonadotropic Gonadal Axis in Male Rats.Acta parasitologica · 2025Article
- Beyond Latency: ChronicBiomedicines · 2025Review
- Chronic inflammation in pregnant women with latent toxoplasmosis and explanation of discordant results of serological tests for toxoplasmosis.Folia parasitologica · 2025Article
- The degree of toxoplasmosis and testicular histomorphometry in rats.Scientific reports · 2024Article
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- Tryptophan metabolism and immune alterations in pregnant Hispanic women with chronic Toxoplasma gondii infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Factors Influencing Tissue Cyst Yield in a Murine Model of Chronic Toxoplasmosis.Infection and immunity · 2023Article
- Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation.Parasitology research · 2022Article
- Associations betweenInternational journal for parasitology. Parasites and wildlife · 2022Article
- Toxoplasmosis is a risk factor for acquiring SARS-CoV-2 infection and a severe course of COVID-19 in the Czech and Slovak population: a preregistered exploratory internet cross-sectional study.Parasites & vectors · 2021Article
- Relationship between Latent Toxoplasmosis and Depression in Clients of a Center for Assisted Reproduction.Pathogens (Basel, Switzerland) · 2021Article
- The relation of secondary sex ratio and miscarriage history with Toxoplasma gondii infection.BMC infectious diseases · 2018Article
- The association of latent toxoplasmosis and level of serum testosterone in humans.BMC research notes · 2018Article
- Depressiveness and Neuroticism in Bartonella Seropositive and Seronegative Subjects-Preregistered Case-Controls Study.Frontiers in psychiatry · 2018Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunosuppression hypothesis suggests that the increased sex ratio in mice and women with latent toxoplasmosis, retarded embryonic growth in the early phases of pregnancy, prolonged pregnancy of Toxoplasma-infected women, and increased prevalence of toxoplasmosis in mothers of children with Down syndrome can be explained by the presumed immunosuppressive effects of latent toxoplasmosis. Here, we searched for indices of immunosuppression in mice experimentally infected with Toxoplasma gondii. Our results showed that mice in the early phase of latent infection exhibited temporarily increased production of interleukin (IL)-12 and decreased production of IL-10. In accordance with the immunosuppression hypothesis, the mice showed decreased production of IL-2 and nitric oxide and decreased proliferation reaction (synthesis of DNA) in the mixed lymphocyte culture in the early and also in the late phases of latent toxoplasmosis. Since about 30% of the world population are latently infected by T. gondii, the toxoplasmosis-associated immunosuppression might have serious public health consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.