ArticleRheumatology international2012
Synovial fluid adenosine deaminase and high-sensitivity C-reactive protein activity in differentiating monoarthritis.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Assessment and diagnosis of the acute hot joint: a systematic review and meta-analysis.Rheumatology (Oxford, England) · 2023Pooled it
- Synovial Fluid Biomarkers in Knee Osteoarthritis: A Systematic Review and Quantitative Evaluation Using BIPEDs Criteria.Cartilage · 2021Pooled it
- Diagnostic accuracy of synovial fluid progranulin vs. C-reactive protein in septic arthritis: a comparative biomarker study.Advances in rheumatology (London, England) · 2026Article
- A Review of Adenosine Deaminase 2 (ADA2) as a Biomarker of Monocyte/Macrophage Activation.Current allergy and asthma reports · 2026Review
- Subclinical inflammation associated with monosodium urate crystal deposition: a cellular and proteomic study in synovial fluid.Frontiers in immunology · 2026Article
- Pathophysiology and Evolving Treatment Options of Septic Arthritis: A Narrative Review.Cureus · 2024Review
- Simple and inexpensive synovial fluid biomarkers for the diagnosis of prosthetic joint infection according to the new EBJIS definition.Journal of bone and joint infection · 2023Article
- Diagnosing Periprosthetic Joint Infection: a Scoping Review.Current reviews in musculoskeletal medicine · 2022Article
- Development a stacking pad design for enhancing the sensitivity of lateral flow immunoassay.Scientific reports · 2018Article
- Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2017Review
- CORR Insights: Is synovial C-reactive protein a useful marker for periprosthetic joint infection?Clinical orthopaedics and related research · 2014Article
- Is synovial C-reactive protein a useful marker for periprosthetic joint infection?Clinical orthopaedics and related research · 2014Article
- Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.Rheumatology international · 2012Article
- A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans.Molecular therapy. Nucleic acids · 2012Article
- Serum adenosine deaminase may predict disease activity in rheumatoid arthritis.Rheumatology international · 2012Article
- Mark B. Coventry Award: synovial C-reactive protein: a prospective evaluation of a molecular marker for periprosthetic knee joint infection.Clinical orthopaedics and related research · 2012Article
- Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice.Arthritis and rheumatism · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is proposed that synovial fluid biomarkers may help in differentiating the type of arthritis. The aim of study is to determine whether synovial fluid adenosine deaminase (ADA) and high-sensitivity C-reactive protein (hs-CRP) can be useful in this regard. A total of 75 patients with knee monoarthritis that were admitted in Shahid Beheshti Kashan hospital in 2009 included in the study. There were 18 rheumatoid arthritis, 13 crystal-induced arthritis, 3 septic arthritis and 41 osteoarthritis. Inflammatory arthritis was diagnosed if more than 2,000 white blood cells existed in per milliliter of the synovial fluid. There was statistically significant difference in mean synovial fluid ADA and hs-CRP concentration between inflammatory (26.06 ± 8.96 IU/l, 12.72 ± 9.25 μg/ml) and non-inflammatory arthritis (14.8 ± 2.79 IU/l, 2.36 ± 2.7 μg/ml) (P values = 0.00, 0.00). There was statistically significant difference in mean synovial fluid ADA and hs-CRP concentration when rheumatoid arthritis (23.77 ± 4.58 IU/l, 10.47 ± 6.99 μg/ml), crystal-induced arthritis (22.76 ± 3.65 IU/l, 14.37 ± 11.58 μg/ml) and septic arthritis (49.66 ± 8.96 IU/l, 18.25 ± 5.37 μg/ml) were compared with osteoarthritis (14.58 ± 2.63 IU/l, 1.91 ± 1.31 μg/ml) (All P values = 0.00). There was statistically significant difference in mean synovial fluid ADA concentration between septic and rheumatoid arthritis and also between septic arthritis and crystal-induced arthritis (P values = 0.00, 0.00). This study showed that synovial fluid ADA and hs-CRP can properly differentiate inflammatory from non-inflammatory arthritis. Synovial fluid ADA is a useful marker in differentiating septic from rheumatoid and crystal-induced arthritis.
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Registered trials
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