ArticleIntensive care medicine2011
Postoperative red blood cell transfusion and morbid outcome in uncomplicated cardiac surgery patients.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial.Intensive care medicine · 2013Trial
- Blood transfusion in cardiac surgery is a risk factor for increased hospital length of stay in adult patients.Journal of cardiothoracic surgery · 2013Trial
- Factors affecting mortality after coronary bypass surgery: a scoping review.Journal of cardiothoracic surgery · 2022Article
- Opportunities Beyond the Anesthesiology Department: Broader Impact Through Broader Thinking.Anesthesia and analgesia · 2022Review
- Pneumonia After Cardiovascular Surgery: Incidence, Risk Factors and Interventions.Frontiers in cardiovascular medicine · 2022Review
- Prediction and prognosis of reintubation after surgery for Stanford type A aortic dissection.Frontiers in cardiovascular medicine · 2022Article
- Evaluation of Plasma Fibrinogen Levels before and after Coronary Artery Bypass Graft Surgery and Its Association with the Need for Blood Products.Advanced biomedical research · 2022Article
- Risk factors for postoperative pneumonia after cardiac surgery: a prediction model.Journal of thoracic disease · 2021Article
- Reoperation for bleeding in an elective cardiac surgical population - Does it affect survival?Journal of cardiovascular and thoracic research · 2021Article
- The Prognostic Significance of Different Bleeding Classifications in off-pump coronary artery bypass grafting.BMC cardiovascular disorders · 2020Article
- Impact of blood transfusion on major infection after isolated coronary artery bypass surgery: Incidence and risk factors.Journal of the Saudi Heart Association · 2019Article
- Hypotensive Epidural Anesthesia Reduces Blood Loss in Pelvic and Sacral Bone Tumor Resections.Clinical orthopaedics and related research · 2017Observational
- Revisiting blood transfusion and predictors of outcome in cardiac surgery patients: a concise perspective.F1000Research · 2017Review
- A Preoperative Risk Model for Postoperative Pneumonia After Coronary Artery Bypass Grafting.The Annals of thoracic surgery · 2016Observational
- Tranexamic acid and orthopedic surgery-the search for the holy grail of blood conservation.Annals of translational medicine · 2015Article
- Blood transfusions in total hip and knee arthroplasty: an analysis of outcomes.TheScientificWorldJournal · 2014Article
- Balancing the benefits and risks of blood transfusions in patients undergoing cardiac surgery: a propensity-matched analysis.Interactive cardiovascular and thoracic surgery · 2013Article
- Blood transfusion and infection after cardiac surgery.The Annals of thoracic surgery · 2013Review
- What's new in transfusion policies?Intensive care medicine · 2013Article
- Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?Intensive care medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate postoperative red blood cell (RBC) transfusion and its association with postoperative cardiac events and multiorgan morbidity in uncomplicated cardiac surgery patients.
methodsA cohort of 945 patients from the 5,436 coronary artery bypass grafting patients enrolled in the international Multicenter Study of Perioperative Ischemia (McSPI) Epidemiology II (EPI II) study was investigated. Inclusion criteria were low to moderate risk profile, postoperative hemoglobin level ≥ 10 g/dl, minimal postoperative blood loss, and no evidence of any morbid event on the day of surgery. RBC transfusion was assessed during the first 24 postoperative hours and cardiac as well as multiorgan outcomes from postoperative day 2 to hospital discharge. Multivariate analysis was applied to assess the effect of RBC transfusion on multiorgan outcomes. A secondary propensity score analysis was performed in 4,465 patients without early postoperative morbid outcomes.
resultsTransfused patients (193/945, 20.4%) were more likely to suffer cardiac events (P = 0.03), harvest-site infection (P = 0.002), and composite morbidity outcome (P = 0.04). RBC transfusion was associated with cardiac events on multivariate as well as on propensity score analysis (adjusted odds ratio, 1.39; 95% confidence interval, 1.01-1.92; P = 0.04), and with harvest-site infection on multivariate analysis. Additionally, propensity score analysis suggested possible associations of RBC transfusion with increased risks for composite morbidity outcome and in-hospital mortality, renal morbidity, pneumonia, and mediastinitis.
conclusionsThe data suggest a potential association between postoperative RBC transfusion and increased morbidity for cardiac surgery patients with low to moderate mortality risk profiles, adequate hemoglobin levels, and low bleeding rates.
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