ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Could Inhibiting the DNA Damage Repair Checkpoint Rescue Immune-Checkpoint-Inhibitor-Resistant Endometrial Cancer?Journal of clinical medicine · 2023Review
- cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer.Current cancer drug targets · 2023Review
- The intersection molecule MDA5 in Cancer and COVID-19.Frontiers in immunology · 2022Review
- Mechanism and effects of STING-IFN-I pathway on nociception: A narrative review.Frontiers in molecular neuroscience · 2022Review
- Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy.Molecular cancer · 2020Review
- Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity.Cell reports · 2020Article
- Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies.Frontiers in immunology · 2018Review
- Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis.Cell death & disease · 2016Article
- Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools.Mediators of inflammation · 2016Review
- Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cross-presentation of cutaneous melanoma antigen by migratory XCR1Oncoimmunology · 2015Article
- Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.Frontiers in immunology · 2015Review
- A subset of human plasmacytoid dendritic cells expresses CD8α upon exposure to herpes simplex virus type 1.Frontiers in microbiology · 2015Article
- The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases.Frontiers in immunology · 2015Review
- STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.Genes and immunity · 2014Article
- Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response.Frontiers in immunology · 2013Review
- Antitumor immune responses mediated by dendritic cells: How signals derived from dying cancer cells drive antigen cross-presentation.Oncoimmunology · 2013Review
- Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?Trends in immunology · 2013Article
- Melanoma-infiltrating dendritic cells: Limitations and opportunities of mouse models.Oncoimmunology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Tumor cell vaccination with irradiated autologous tumor cells is a promising approach to activate tumor-specific T cell responses without the need for tumor Ag identification. However, uptake of dying cells by dendritic cells (DCs) is generally a noninflammatory or tolerizing event to prevent the development of autoreactive immune responses. In this study, we describe the mechanisms that confer the potent T cell priming capacity of a recently identified a population of DCs (merocytic DCs [mcDCs]) that potently primes both CD8(+) and CD4(+) T cells to cell-associated Ags upon uptake of apoptotic cells. mcDCs acquired cell-associated materials through a process of merocytosis that is defined by the uptake of small particles that are stored in nonacidic compartments for prolonged periods, sustained Ag presentation, and the induction of type I IFN. T cells primed by mcDCs to cell-associated Ags exhibit increased primary expansion, enhanced effector function, and increased memory formation. By using transgenic T cell transfer models and endogenous models, we show that treatment of tumor-bearing mice with mcDCs that have been exposed to dying tumor cells results in tumor suppression and increased host survival through the activation of naive tumor-specific CD8(+) T cells as well as the reinvigoration of tumor-specific T cells that had been rendered nonresponsive by the tumor in vivo. The potent capacity of mcDCs to prime both CD4(+) and CD8(+) T cells to cell-associated Ags under immunosuppressive conditions makes this DC subset an attractive target for tumor therapies as well as interventional strategies for autoimmunity and transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.