ArticleMolecular biology of the cell2010
Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 53 citations in OpenAlex.
- Sprouty in Tumors of the Nervous System.International journal of molecular sciences · 2025Review
- Role of miR-21-5p in the pathogenesis of abdominal aortic aneurysm regarding the Th17 pathway.International journal of cardiology. Heart & vasculature · 2025Article
- MNK: A Novel Promising Target for Cancer Immunotherapy.Current medicinal chemistry · 2025Review
- Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells.Cells · 2024Article
- Examining the Effects of Gestational Physical Activity and Hofbauer Cell Polarization on Angiogenic Factors.International journal of environmental research and public health · 2023Article
- Review
- Review
- Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.International journal of molecular sciences · 2021Article
- Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.PLoS biology · 2021Article
- A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes.International journal of molecular sciences · 2021Article
- Review
- Article
- Sprouty2-a Novel Therapeutic Target in the Nervous System?Molecular neurobiology · 2019Review
- The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)PThe Journal of biological chemistry · 2018Article
- Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities.JCI insight · 2018Article
- Sprouty branches out to control T cell memory.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Lack of Sprouty 1 and 2 enhances survival of effector CD8Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.Nature communications · 2018Article
- A Whole-Genome RNA Interference Screen Reveals a Role forDiabetes · 2017Article
- Programs for the persistence, vigilance and control of human CD8Nature immunology · 2016Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
Abstract
Sprouty (Spry) proteins are negative regulators of receptor tyrosine kinase signaling; however, their exact mechanism of action remains incompletely understood. We identified phosphatidylinositol-specific phospholipase C (PLC)-γ as a partner of the Spry1 and Spry2 proteins. Spry-PLCγ interaction was dependent on the Src homology 2 domain of PLCγ and a conserved N-terminal tyrosine residue in Spry1 and Spry2. Overexpression of Spry1 and Spry2 was associated with decreased PLCγ phosphorylation and decreased PLCγ activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals. Overexpression of Spry 1 or Spry2 or small-interfering RNA-mediated knockdown of PLCγ1 or PLCγ2 abrogated the activity of a calcium-dependent reporter gene, suggesting that Spry inhibited calcium-mediated signaling downstream of PLCγ. Furthermore, Spry overexpression in T-cells, which are highly dependent on PLCγ activity and calcium signaling, blocked T-cell receptor-mediated calcium release. Accordingly, cultured T-cells from Spry1 gene knockout mice showed increased proliferation in response to T-cell receptor stimulation. These data highlight an important action of Spry, which may allow these proteins to influence signaling through multiple receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.