ArticleMolecular biology of the cell2010
Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- CEP170 as a novel molecular link between centrosomal function and cerebral cortical development.Journal of biomedical science · 2026Article
- Cilia proteins getting to work - how do they commute from the cytoplasm to the base of cilia?Journal of cell science · 2022Review
- Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.Cell research · 2022Article
- Function of Centriolar Satellites and Regulation by Post-Translational Modifications.Frontiers in cell and developmental biology · 2021Review
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- Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.Scientific reports · 2019Article
- Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.Protoplasma · 2019Article
- Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.Cell death & disease · 2019Article
- Spatial and proteomic profiling reveals centrosome-independent features of centriolar satellites.The EMBO journal · 2019Article
- A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.Science (New York, N.Y.) · 2019Article
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- Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation.Molecular biology of the cell · 2017Article
- The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.Journal of cell science · 2017Article
- Regulation of centriolar satellite integrity and its physiology.Cellular and molecular life sciences : CMLS · 2017Review
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- Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration.Scientific reports · 2016Article
- Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry.Molecular biology of the cell · 2016Article
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- Centriolar satellites: key mediators of centrosome functions.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The centrosome contains proteins that control the organization of the microtubule cytoskeleton in interphase and mitosis. Its protein composition is tightly regulated through selective and cell cycle-dependent recruitment, retention, and removal of components. However, the mechanisms underlying protein delivery to the centrosome are not completely understood. We describe a novel function for the polarity protein Par6α in protein transport to the centrosome. We detected Par6α at the centrosome and centriolar satellites where it interacted with the centriolar satellite protein PCM-1 and the dynactin subunit p150(Glued). Depletion of Par6α caused the mislocalization of p150(Glued) and centrosomal components that are critical for microtubule anchoring at the centrosome. As a consequence, there were severe alterations in the organization of the microtubule cytoskeleton in the absence of Par6α and cell division was blocked. We propose a model in which Par6α controls centrosome organization through its association with the dynactin subunit p150(Glued).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.