ArticleJournal of neurophysiology2010
Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Molecular Disambiguation of Heart Rate Control by the Nucleus Ambiguus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mandibular extension as a trigger of the proprioceptive trigeminocardiac reflex.Turkish journal of medical sciences · 2026Review
- Beyond the airway: the impact of septoplasty and turbinate reduction on somnolence and sleep disordered breathing risk-a prospective study.Frontiers in surgery · 2026Article
- Intra-operative hypertension as a predictor of surgical outcomes in microvascular decompression surgery for trigeminal neuralgia.Acta neurochirurgica · 2024Article
- Trigeminal nerve stimulation: a current state-of-the-art review.Bioelectronic medicine · 2023Review
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Developmental nicotine exposure alters cholinergic control of respiratory frequency in neonatal rats.Developmental neurobiology · 2016Article
- Sudden Infant Death Syndrome - Role of Trigeminocardiac Reflex: A Review.Frontiers in neurology · 2016Review
- Parasympathetic preganglionic cardiac motoneurons labeled after voluntary diving.Frontiers in physiology · 2014Article
- Mast cells in the human dura: effects of age and dural bleeding--authors' reply.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- An autonomic link between inhaled diesel exhaust and impaired cardiac performance: insight from treadmill and dobutamine challenges in heart failure-prone rats.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- The mammalian diving response: an enigmatic reflex to preserve life?Physiology (Bethesda, Md.) · 2013Review
- Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- The pathophysiology of brain swelling associated with subdural hemorrhage: the role of the trigeminovascular system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- Developmental changes in human dural innervation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Anaesthetics differentially modulate the trigeminocardiac reflex excitatory synaptic pathway in the brainstem.The Journal of physiology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Stimulation of the nasal mucosa by airborne irritants or water evokes a pronounced bradycardia accompanied by peripheral vasoconstriction and apnea. The dive response, which includes the trigeminocardiac reflex, is among the most powerful autonomic responses. These responses slow the heart rate and reduce myocardial oxygen consumption. Although normally cardioprotective, exaggeration of this reflex can be detrimental and has been implicated in cardiorespiratory diseases, including sudden infant death syndrome (SIDS). An essential component of the diving response and trigeminocardiac reflex is activation of the parasympathetic cardiac vagal neurons (CVNs) in the nucleus ambiguus that control heart rate. This study examined the involvement of cholinergic receptors in trigeminally evoked excitatory postsynaptic currents in CVNs in an in vitro preparation from rats. CVNs were identified using a retrograde tracer injected into the fat pads at the base of the heart. Application of the acetylcholinesterase inhibitor neostigmine significantly decreased the amplitude of glutamatergic neurotransmission to CVNs on stimulation of trigeminal fibers. Whereas nicotine did not have any effect on the glutamatergic responses, the muscarinic acetylcholine receptor (mAChR) agonist bethanechol significantly decreased the excitatory neurotransmission. Atropine, an mAChR antagonist, facilitated these responses indicating this trigeminally evoked brain stem pathway in vitro is endogenously inhibited by mAChRs. Tropicamide, an m4 mAChR antagonist, prevented the inhibitory action of the muscarinic agonist bethanechol. These results indicate that the glutamatergic synaptic neurotransmission in the trigeminally evoked pathway to CVNs is endogenously inhibited in vitro by m4 mAChRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.