ArticleJournal of neurophysiology2010
Molecular layer inhibitory interneurons provide feedforward and lateral inhibition in the dorsal cochlear nucleus.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Identification and quantification of GABAIBRO neuroscience reports · 2025Article
- The NaeLife · 2024Article
- Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception.Brain : a journal of neurology · 2023Review
- The NabioRxiv : the preprint server for biology · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Descending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inhibitory interneurons in a brainstem circuit adjust their inhibitory motifs to process multimodal input.The Journal of physiology · 2021Article
- Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.Science (New York, N.Y.) · 2019Article
- Kv3 KNeuropharmacology · 2018Article
- A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.Hearing research · 2018Article
- β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.Cell reports · 2016Article
- Auditory Golgi cells are interconnected predominantly by electrical synapses.Journal of neurophysiology · 2016Article
- Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.Neurobiology of disease · 2015Article
- Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus.Neuron · 2014Article
- Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.Journal of neurophysiology · 2014Article
- Cell-type specific short-term plasticity at auditory nerve synapses controls feed-forward inhibition in the dorsal cochlear nucleus.Frontiers in neural circuits · 2014Article
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2 authors.
Funding
Abstract
In the outer layers of the dorsal cochlear nucleus, a cerebellum-like structure in the auditory brain stem, multimodal sensory inputs drive parallel fibers to excite both principal (fusiform) cells and inhibitory cartwheel cells. Cartwheel cells, in turn, inhibit fusiform cells and other cartwheel cells. At the microcircuit level, it is unknown how these circuit components interact to modulate the activity of fusiform cells and thereby shape the processing of auditory information. Using a variety of approaches in mouse brain stem slices, we investigated the synaptic connectivity and synaptic strength among parallel fibers, cartwheel cells, and fusiform cells. In paired recordings of spontaneous and evoked activity, we found little overlap in parallel fiber input to neighboring neurons, and activation of multiple parallel fibers was required to evoke or alter action potential firing in cartwheel and fusiform cells. Thus neighboring neurons likely respond best to distinct subsets of sensory inputs. In contrast, there was significant overlap in inhibitory input to neighboring neurons. In recordings from synaptically coupled pairs, cartwheel cells had a high probability of synapsing onto nearby fusiform cells or other nearby cartwheel cells. Moreover, single cartwheel cells strongly inhibited spontaneous firing in single fusiform cells. These synaptic relationships suggest that the set of parallel fibers activated by a particular sensory stimulus determines whether cartwheel cells provide feedforward or lateral inhibition to their postsynaptic targets.
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