Evidence map›Paper›PMID 20719902›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2010

Body size and incident colorectal cancer: a prospective study of older women.

Amy S Oxentenko, Aditya Bardia, Robert A Vierkant, Alice H Wang, Kristin E Anderson, Peter T Campbell, Thomas A Sellers, Aaron R Folsom, James R Cerhan, Paul J Limburg

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 9 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 9 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  5. Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review, and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Pooled it
  6. Pooled it
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
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  17. Article
  18. Early-life obesity and adulthood colorectal cancer risk: a meta-analysis.Revista panamericana de salud publica = Pan American journal of public health · 2019
    Review
  19. Early Life Exposures and Adult Cancer Risk.Epidemiologic reviews · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Amy S OxentenkoCollege of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Aditya Bardia
Robert A Vierkant
Alice H Wang
Kristin E Anderson
Peter T Campbell
Thomas A Sellers
Aaron R Folsom
James R Cerhan
Paul J Limburg
Moffitt Cancer Center · USJohns Hopkins University · USSidney Kimmel Comprehensive Cancer Center · USAmerican Cancer Society · USMayo Clinic in Florida · US

Funding

EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
Molecular Epidemiology of Colorectal Cancer SubtypesR01CA107333 · NCI · MAYO CLINIC ROCHESTER · PI LIMBURG, PAUL J · 2005 to 2010
$1.4M
NCI NIH HHS R01 CA107333NCI NIH HHS R01 CA39742
6 · The paper itself

Abstract

Obesity is a controversial risk factor for colorectal cancer (CRC) in older women. We evaluated associations between multiple body size parameters and incident CRC in the prospective, population-based Iowa Women's Health Study (IWHS). IWHS participants, ages 55 to 69 years, provided data regarding height; weight; weight at ages 50, 40, 30, 18 years; hip circumference; and waist circumference at baseline (1986). Derived variables included body mass index (BMI), waist-to-hip ratio (WHR), and "overweight years" (OWY; conceptually similar to cigarette pack-years). Incident CRC cases (n = 1,464) were ascertained from the State Health Registry of Iowa, through 2005. Multivariable Cox regression models were fit to estimate body size-associated CRC risks. Among 36,941 women (619,961 person-years), baseline height, weight, BMI, hip circumference, waist circumference, and WHR were all positively associated with incident CRC (P(trend) ≤ 0.003 for each). Baseline BMI yielded the highest CRC risk estimates (obese III versus normal, RR = 1.56; 95% CI = 1.10-2.22; P(trend) < 0.001) and was more closely associated with distal than proximal tumors (P(trend) < 0.001 versus 0.06). Conversely, height was more closely associated with proximal than distal tumors (P(trend) < 0.001 versus 0.04). Other body size parameters were less predictive of incident CRC. These data strongly support a positive association between increased body size and CRC risk among older women. Further investigation of when increased body size has the greatest effect on CRC risk (i.e., early adulthood versus later adulthood) might also be informative, particularly with respect to defining subsite-specific pathways of colorectal carcinogenesis.

Indexed as

Body SizeAgedBody Mass IndexBody WeightColorectal NeoplasmsFemaleHumansIowaMiddle AgedObesityProspective StudiesRegistriesRisk FactorsWaist-Hip Ratio

Identifiers

PMID20719902
PMCPMC3005991
OpenAlexW2101847949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.