Interpreting composite outcomes in trials.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Sample size requirement in trials that use the composite endpoint major adverse cardiovascular events (MACE): new insights.Trials · 2022
   Pooled it
2. Composite adverse outcomes in obstetric studies: a systematic review.BMC pregnancy and childbirth · 2021
   Pooled it
3. Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study.Health technology assessment (Winchester, England) · 2020
   Trial
4. Responsiveness of Single versus Composite Measures of Pain in Knee Osteoarthritis.The Journal of rheumatology · 2018
   Trial
5. Bin-CE: A comprehensive web application to decide upon the best set of outcomes to be combined in a binary composite endpoint.PloS one · 2018
   Article
6. Why clinical trial outcomes fail to translate into benefits for patients.Trials · 2017
   Article
7. Long-term risk of myocardial infarction and stroke in bipolar I disorder: A population-based Cohort Study.Journal of affective disorders · 2016
   Article
8. Can we deliver randomized trials of focal therapy in prostate cancer?Nature reviews. Clinical oncology · 2014
   Review
9. Identifying outcomes of clinical genetic services: qualitative evidence and methodological considerations.Journal of genetic counseling · 2014
   Article
10. Endpoint selection and relative (versus absolute) risk reporting in published medication trials.Journal of general internal medicine · 2011
    Article
11. Delphi-consensus weights for ischemic and bleeding events to be included in a composite outcome for RCTs in thrombosis prevention.PloS one · 2011
    Article

Corrections and comments

• Comment on
  Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review.2010

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as