ArticleInternational journal of epidemiology2010
Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link.
Article in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Controlling for polygenic genetic confounding in epidemiologic association studies.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols.Environmental health perspectives · 2020Article
- Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps?Development and psychopathology · 2018Review
- COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study.Scientific reports · 2016Article
- Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures.Behavior genetics · 2016Review
- Separating Family-Level and Direct Exposure Effects of Smoking During Pregnancy on Offspring Externalizing Symptoms: Bridging the Behavior Genetic and Behavior Teratologic Divide.Behavior genetics · 2016Article
- Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family-Based Quasi-Experimental Designs.Child development perspectives · 2014Article
- Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance.Behavior genetics · 2014Article
- Stress-related eating, obesity and associated behavioural traits in adolescents: a prospective population-based cohort study.BMC public health · 2014Article
- A sibling-comparison study of smoking during pregnancy and childhood psychological traits.Behavior genetics · 2014Article
- Critical need for family-based, quasi-experimental designs in integrating genetic and social science research.American journal of public health · 2013Article
- The epigenetics of maternal cigarette smoking during pregnancy and effects on child development.Development and psychopathology · 2012Review
- Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors.Psychological medicine · 2012Article
- Is maternal smoking during pregnancy a causal environmental risk factor for adolescent antisocial behavior? Testing etiological theories and assumptions.Psychological medicine · 2012Article
- Maternal personality traits associated with patterns of prenatal smoking and exposure: Implications for etiologic and prevention research.Neurotoxicology and teratologyArticle
- Impact of prenatal exposure characterization on early risk detection: Methodologic insights for the HEALthy Brain and Child Development (HBCD) study.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn utero exposure to tobacco smoking has been suggested to cause persistent alterations in cognitive functioning. We examined if mothers' smoking during pregnancy (SDP) is associated with long-term impairment in offspring stress coping and the causal mechanism behind a possible link.
methodsWe used a large cohort (n = 187,106) of young males in Sweden (mean age = 18.2 years), who underwent a semi-structured psychological assessment in 1997-2006, including an evaluation of stress coping ability, as part of the compulsory military conscript examination. We compared differentially exposed siblings within nuclear families and cousins in extended families and used multilevel structural equation models to disentangle genetic from environmental contributions to the association between SDP and stress coping.
resultsSDP and offspring stress coping was moderately strongly associated when comparing unrelated individuals [regression coefficient (b) = -0.38 on a nine-point scale; 95% confidence interval (CI) -0.40 to -0.36, P < 0.0001]. In contrast, it disappeared when siblings were compared (b = 0.11; 95% CI -0.01 to 0.23, P = 0.071). This familial confounding was entirely due to genetic influences.
conclusionsSDP is an established risk factor for pregnancy- and birth-related complications. However, we found no long-term effect of SDP on offspring stress coping. Rather, the observed association was due to familial confounding of genetic origin; women prone to SDP also transmit genes to their children that are associated with poorer coping with stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.