ArticleEuropean journal of cell biology
Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton.
Article in European journal of cell biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease.Nature communications · 2023Article
- Proteomic Markers for Mechanobiological Properties of Metastatic Cancer Cells.International journal of molecular sciences · 2023Review
- The Actin Network Interfacing Diverse Integrin-Mediated Adhesions.Biomolecules · 2023Review
- Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions.Frontiers in cell and developmental biology · 2020Review
- Article
- Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.Molecular neurobiology · 2019Article
- Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression.Oncotarget · 2015Article
- Dasatinib suppresses invasion and induces apoptosis in nasopharyngeal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Regulation of invadopodia by the tumor microenvironment.Cell adhesion & migration · 2014Review
- Coupling between acto-adhesive machinery and ECM degradation in invadosomes.Cell adhesion & migration · 2014Review
- Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Regulation of osteoclasts by membrane-derived lipid mediators.Cellular and molecular life sciences : CMLS · 2013Review
- Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes.PloS one · 2013Article
- Label-free recognition of drug resistance via impedimetric screening of breast cancer cells.PloS one · 2013Article
- RNA therapeutics targeting osteoclast-mediated excessive bone resorption.Advanced drug delivery reviews · 2012Review
- Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.The Journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell adhesion to the extracellular matrix is mediated by adhesion receptors, mainly integrins, which upon interaction with the extracellular matrix, bind to the actin cytoskeleton via their cytoplasmic domains. This association is mediated by a variety of scaffold and signaling proteins, which control the mechanical and signaling activities of the adhesion site. Upon transformation of fibroblasts with active forms of Src (e.g., v-Src), focal adhesions are disrupted, and transformed into dot-like contacts known as podosomes, and consisting of a central actin core surrounded by an adhesion ring. To clarify the mechanism underlying Src-dependent modulation of the adhesive phenotype, and its influence on podosome organization, we screened for the effect of siRNA-mediated knockdown of tyrosine kinases, MAP kinases and phosphatases on the reorganization of the adhesion-cytoskeleton complex, induced by a constitutively active Src mutant (SrcY527F). In this screen, we discovered several genes that are involved in Src-induced remodeling of the actin cytoskeleton. We further showed that knockdown of Src in osteoclasts abolishes the formation of the podosome-based rings and impairs cell spreading, without inducing stress fiber development. Our work points to several genes that are involved in this process, and sheds new light on the molecular plasticity of integrin adhesions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.