ArticleBiomaterials2010
Transparent magnetic photoresists for bioanalytical applications.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Microscale magnetic field modulation using rapidly patterned soft magnetic microstructures.RSC advances · 2021Article
- A technology of a different sort: microraft arrays.Lab on a chip · 2021Review
- Design of an automated capillary electrophoresis platform for single-cell analysis.Methods in enzymology · 2019Review
- Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma.Biosensors & bioelectronics · 2014Article
- Time-resolved digital holographic microscopy of laser-induced forward transfer process.Applied physics. B, Lasers and optics · 2014Article
- Scalable synthesis of a biocompatible, transparent and superparamagnetic photoresist for microdevice fabrication.Journal of micromechanics and microengineering : structures, devices, and systems · 2013Article
- Isolation and in vitro culture of rare cancer stem cells from patient-derived xenografts of pancreatic ductal adenocarcinoma.Analytical chemistry · 2013Article
- Laser-based directed release of array elements for efficient collection into targeted microwells.The Analyst · 2013Article
- Isolation and manipulation of living adherent cells by micromolded magnetic rafts.Biomicrofluidics · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Microfabricated devices possessing magnetic properties are of great utility in bioanalytical microdevices due to their controlled manipulation with external magnets. Current methods for creating magnetic microdevices yield a low-transparency material preventing light microscopy-based inspection of biological specimens on the structures. Uniformly transparent magnetic photoresists were developed for microdevices that require high transparency as well as consistent magnetism across the structure. Colloidal formation of 10 nm maghemite particles was minimized during addition to the negative photoresists SU-8 and 1002F through organic capping of the nanoparticles and utilization of solvent-based dispersion techniques. Photoresists with maghemite concentrations of 0.01-1% had a high transparency due to the even dispersal of maghemite nanoparticles within the polymer as observed with transmission electron microscopy (TEM). These magnetic photoresists were used to fabricate microstructures with aspect ratios up to 4:1 and a resolution of 3 μm. Various cell lines showed excellent adhesion and viability on the magnetic photoresists. An inspection of cells cultured on the magnetic photoresists with TEM showed cellular uptake of magnetic nanoparticles leeched from the photoresists. Cellular contamination by magnetic nanoparticles was eliminated by capping the magnetic photoresist surface with native 1002F photoresist or by removing the top layer of the magnetic photoresist through surface roughening. The utility of these magnetic photoresists was demonstrated by sorting single cells (HeLa, RBL and 3T3 cells) cultured on arrays of releasable magnetic micropallets. 100% of magnetic micropallets with attached cells were collected following release from the array. 85-92% of the collected cells expanded into colonies. The polymeric magnetic materials should find wide use in the fabrication of microstructures for bioanalytical technologies.
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