Trial reportClinical endocrinology2010
Recombinant human prolactin for the treatment of lactation insufficiency.
Trial report in Clinical endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00181649 (Recombinant Human Prolactin for Lactation Induction in Adoptive Mothers), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recombinant Human Prolactin for Lactation Induction in Adoptive Mothers
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Acupoint stimulation for postpartum breastfeeding insufficiency: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants.The Cochrane database of systematic reviews · 2012Pooled it
- Effects of recombinant human prolactin on breast milk composition.Pediatrics · 2011Trial
- Breastfeeding in panhypopituitarism: a case report, review of the literature, and management checklist.International breastfeeding journal · 2026Review
- A long-lasting prolactin stimulates galactopoiesis in mice.iScience · 2025Article
- Neuropsychological complications of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Prolactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.Reviews in endocrine & metabolic disorders · 2024Review
- The molecular basis of hypoprolactinaemia.Reviews in endocrine & metabolic disorders · 2024Review
- Diagnosis of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Investigating the effect of quail egg supplementation enriched with marine macroalgaeOpen veterinary journal · 2024Article
- A long-acting prolactin to combat lactation insufficiency.bioRxiv : the preprint server for biology · 2023Article
- Isolated anterior pituitary dysfunction in adulthood.Frontiers in endocrinology · 2023Review
- Cardiometabolic profile of young women with hypoprolactinemia.Endocrine · 2022Article
- Management of Hypopituitarism.Journal of clinical medicine · 2019Review
- Prolactin - a pleiotropic factor in health and disease.Nature reviews. Endocrinology · 2019Review
- What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?-A Narrative Review.Nutrients · 2019Review
- Current and emerging treatment options for spinal muscular atrophy.Degenerative neurological and neuromuscular disease · 2015Review
- Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats.Hormones and behavior · 2014Article
- The role of maternal care in shaping CNS function.Neuropeptides · 2013Review
- Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells.The Journal of clinical endocrinology and metabolism · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
contextLactation insufficiency has many aetiologies including complete or relative prolactin deficiency. Exogenous prolactin may increase breast milk volume in this subset. We hypothesized that recombinant human prolactin (r-hPRL) would increase milk volume in mothers with prolactin deficiency and mothers of preterm infants with lactation insufficiency.
designStudy 1: R-hPRL was administered in an open-label trial to mothers with prolactin deficiency. Study 2: R-hPRL was administered in a randomized, double-blind, placebo-controlled trial to mothers with lactation insufficiency that developed while pumping breast milk for their preterm infants. PATIENTS: Study 1: Mothers with prolactin deficiency (n = 5). Study 2: Mothers of premature infants exclusively pumping breast milk (n = 11).
designStudy 1: R-hPRL (60 μg/kg) was administered subcutaneously every 12 h for 28 days. Study 2: Mothers of preterm infants were randomized to receive r-hPRL (60 μg/kg), placebo or r-hPRL alternating with placebo every 12 h for 7 days. MEASUREMENTS: Change in milk volume.
resultsStudy 1: Peak prolactin (27·9 ± 17·3 to 194·6 ± 19·5 μg/l; P < 0·003) and milk volume (3·4 ± 1·6 to 66·1 ± 8·3 ml/day; P < 0·001) increased with r-hPRL administration. Study 2: Peak prolactin increased in mothers treated with r-hPRL every 12 h (n = 3; 79·3 ± 55·4 to 271·3 ± 36·7 μg/l; P < 0·05) and daily (101·4 ± 61·5 vs 178·9 ± 45·9 μg/l; P < 0·04), but milk volume increased only in the group treated with r-hPRL every 12 h (53·5 ± 48·5 to 235·0 ± 135·7 ml/day; P < 0·02).
conclusionTwice daily r-hPRL increases milk volume in mothers with prolactin deficiency and in preterm mothers with lactation insufficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.