ArticleCroatian medical journal2010
Human brucellosis in Macedonia - 10 years of clinical experience in endemic region.
Article in Croatian medical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Updated therapeutic options for human brucellosis: A systematic review and network meta-analysis of randomized controlled trials.PLoS neglected tropical diseases · 2024Pooled it
- Methodological choices in brucellosis burden of disease assessments: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Pediatric brucellosis: predictors of hospitalization, complications, and relapse in a nationwide multicenter cohort.European journal of pediatrics · 2026Article
- Comparison of sitafloxacin monotherapy versus doxycycline plus rifampicin for acute uncomplicated human brucellosis: a multicenter, randomized, open-label, non-inferiority trial.The Lancet regional health. Western Pacific · 2026Article
- Retrospective Analysis of Epidemiologic, Clinical, and Laboratory Findings of Patients Diagnosed with Brucellosis and Review of the Literature.Infectious diseases & clinical microbiology · 2026Article
- Extracellular vesicle microRNA signature as a highly accurate diagnostic biomarker for human brucellosis.Frontiers in cellular and infection microbiology · 2026Article
- Evaluation of Human Brucellosis Patients with Post-Treatment Standard Tube Agglutination Test Titers.Pathogens (Basel, Switzerland) · 2025Article
- Human herpesvirus type 4 combined with Brucella abortus meningitis case report.BMC infectious diseases · 2025Article
- Brucella Pneumonia Mimicking Pulmonary Tuberculosis: A Case Report.Clinical case reports · 2025Article
- Article
- Case Report: Neurobrucellosis Presenting as Malignancy.The American journal of tropical medicine and hygiene · 2024Article
- Video-Assisted Thoracoscopic Surgery (VATS) Decortication for the Management ofJournal of clinical practice and research · 2024Article
- Demographic characteristics, laboratory features and complications in 346 cases of brucellosis: A retrospective study from Qatar.IJID regions · 2024Article
- Review
- Brucella infection presenting as infective endocarditis complicated by embolic stroke.IDCases · 2024Article
- A Misdiagnosis of Brucellosis Leads to Prosthetic Valve Endocarditis Complicated by Cerebrovascular Accident.Case reports in infectious diseases · 2024Article
- Seroprevalence and associated risk factors of brucellosis, Rift Valley fever and Q fever among settled and mobile agro-pastoralist communities and their livestock in Chad.PLoS neglected tropical diseases · 2023Article
- Recurrent Neurobrucellosis in a Feral Swine Hunter.Cureus · 2023Article
- Case report of pulmonary brucellosis complicated by pleural effusion.Respiratory medicine case reports · 2023Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.
methodsA total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes.
resultsOf the 550 patients, 395 (72%) were male. The median age was 34.5 years (range, 1-82). Direct contact with infected animals was recorded in 333 (61%) patients and positive family history in 310 (56%). The most frequently seen symptoms were arthralgia (438, 80%), fever (419, 76%), and sweating (394, 72%). The most common signs were fever and hepatomegaly, which were verified in 357 (65%) and 273 (50%) patients, respectively. Focal brucellosis was found in 362 patients (66%) and osteoarticular in 299 (54%). Therapeutic failures were registered in 37 (6.7%) patients. Of the 453 (82%) patients who completed a follow-up period of at least 6 months, relapses occurred in 60 (13%).
conclusionDue to non-specific clinical manifestation and laboratory parameters, brucellosis should be considered one of the differential diagnoses of any patient suffering from obscure involvement of various organs in a brucellosis-endemic region. High percentage of relapses and therapeutic failures in spite of the use of currently recommended therapeutic regimens indicates the seriousness of this zoonosis and the need to control it.
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