Trial reportPlanta medica2011
Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.
Trial report in Planta medica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo "connect".Journal of clinical pharmacology · 2013Trial
- A review of the pharmacological mechanism of corosolic acid.Frontiers in pharmacology · 2026Review
- Pentacyclic Triterpenoid Content in Cranberry Raw Materials and Products.Foods (Basel, Switzerland) · 2024Article
- Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine.Pharmaceutics · 2021Review
- Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach.Pharmacological reviews · 2021Review
- Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound.Oncology letters · 2021Review
- Pheophorbide Derivatives Isolated from Açaí Berries (Natural product communications · 2019Article
- Interaction between phytotherapy and oral anticancer agents: prospective study and literature review.Medical oncology (Northwood, London, England) · 2019Review
- Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Drug metabolism and disposition: the biological fate of chemicals · 2018Article
- Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.International journal of molecular sciences · 2017Review
- Botanicals and Their Bioactive Phytochemicals for Women's Health.Pharmacological reviews · 2016Review
- Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report.Cureus · 2016Article
- Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences.European journal of drug metabolism and pharmacokinetics · 2016Review
- Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.Drug metabolism and disposition: the biological fate of chemicals · 2014Article
- Herb-drug interactions: challenges and opportunities for improved predictions.Drug metabolism and disposition: the biological fate of chemicals · 2014Article
- Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Pharmacology & therapeutics · 2012Review
- An overview of the evidence and mechanisms of herb-drug interactions.Frontiers in pharmacology · 2012Article
- Effect of cranberry dietary supplements with different brands on human CYP3A4 enzyme.EXCLI journal · 2012Article
- Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Influence of dietary substances on intestinal drug metabolism and transport.Current drug metabolism · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cranberry juice is used routinely, especially among women and the elderly, to prevent and treat urinary tract infections. These individuals are likely to be taking medications concomitantly with cranberry juice, leading to concern about potential drug-dietary substance interactions, particularly in the intestine, which, along with the liver, is rich in expression of the prominent drug metabolizing enzyme, cytochrome P450 3A (CYP3A). Using a systematic in vitro-in vivo approach, a cranberry juice product was identified recently that elicited a pharmacokinetic interaction with the CYP3A probe substrate midazolam in 16 healthy volunteers. Relative to water, cranberry juice inhibited intestinal first-pass midazolam metabolism. In vitro studies were initiated to identify potential enteric CYP3A inhibitors from cranberry via a bioactivity-directed fractionation approach involving dried whole cranberry [Vaccinium macrocarpon Ait. (Ericaceae)], midazolam, and human intestinal microsomes (HIM). Three triterpenes (maslinic acid, corosolic acid, and ursolic acid) were isolated. The inhibitory potency (IC(50)) of maslinic acid, corosolic acid, and ursolic acid was 7.4, 8.8, and < 10 µM, respectively, using HIM as the enzyme source and 2.8, 4.3, and < 10 µM, respectively, using recombinant CYP3A4 as the enzyme source. These in vitro inhibitory potencies, which are within the range of those reported for two CYP3A inhibitory components in grapefruit juice, suggest that these triterpenes may have contributed to the midazolam-cranberry juice interaction observed in the clinical study.
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