ArticleMolecular and cellular biochemistry2010
Naringenin promote apoptosis in cerebrally implanted C6 glioma cells.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Promising leads against lung cancer from the plants in Lamiaceae family.BioImpacts : BI · 2025Review
- BCL2L1 is identified as a target of naringenin in regulating ovarian cancer progression.Molecular and cellular biochemistry · 2022Article
- Neuraminidase Inhibitor ofMolecules (Basel, Switzerland) · 2022Article
- Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway.Molecular biology reports · 2021Article
- Bilberry (Antioxidants (Basel, Switzerland) · 2020Article
- Naringenin Sensitizes Resistant C6 Glioma Cells with a Repressive Impact on the Migrating Ability.Annals of neurosciences · 2020Article
- A Review on Pharmacological and Analytical Aspects of Naringenin.Chinese journal of integrative medicine · 2018Review
- In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity.Molecules (Basel, Switzerland) · 2017Article
- Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?Nutrients · 2016Review
- Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells.Experimental and therapeutic medicine · 2016Article
- Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer.Cancer cell international · 2015Article
- Tumor growth attenuating effects of naringenin.Pathology oncology research : POR · 2014Article
- Plausible role of naringenin against cerebrally implanted C6 glioma cells in rats.Molecular and cellular biochemistry · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naringenin (NGEN), a naturally occurring citrus flavonone, has shown cytotoxicity in various human cancer cell lines as well as inhibitory effects on tumor growth. It has been also shown to access the brain and there is an increasing interest in its therapeutic applications. The up-regulated expression of Cx43 leads to the suppression of tumorigenicity with promoted apoptotic events. In this study, we investigated the in vivo effect of NGEN in fostering apoptosis in cerebrally implanted C6 glioma cells rat model. We analysed the expression of Cx43, caspase-3, caspase-9, Cyt C, Bcl-2 and Bax in vivo by immunoblot analysis and the ultra structure of brain cells by transmission electron microscopy. Supplementation of NGEN to experimental animals modulated Bcl-2/Bax ratio and up-regulation of caspase-3 and 9. NGEN was also found to up-regulate the expression of Cx43. These findings provide evidence that NGEN's apoptotic effect, modulation of Bcl-2/Bax ratio leads to release of Cyt C from mitochondria, thereby activation of caspase-3 and caspase-9 is mediated by enhanced expression of Cx43. These observations were well supported by the transmission electron microscopic results which showed the characteristic apoptotic features. In conclusion, our findings demonstrate that NGEN promotes apoptosis in rat C6 glioma model.
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