ReviewThe EMBO journal2010
Spatial cycles in G-protein crowd control.
Review in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning.The EMBO journal · 2025Article
- Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ.The journal of physical chemistry. B · 2018Article
- Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.Nature communications · 2017Article
- Membrane orientation dynamics of lipid-modified small GTPases.Small GTPases · 2017Review
- Synthetic mechanobiology: engineering cellular force generation and signaling.Current opinion in biotechnology · 2016Review
- Spatial Control of Biochemical Modification Cascades and Pathways.Biophysical journal · 2015Article
- Covalent modification cycles through the spatial prism.Biophysical journal · 2013Article
- Complexity of receptor tyrosine kinase signal processing.Cold Spring Harbor perspectives in biology · 2013Review
- Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticles.Nature nanotechnology · 2013Article
- Subcellular control of Rac-GTPase signalling by magnetogenetic manipulation inside living cells.Nature nanotechnology · 2013Article
- G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- Article
- Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.Nature chemical biology · 2011Article
- Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature of living systems and their apparent resilience to the second law of thermodynamics has been the subject of extensive investigation and imaginative speculation. The segregation and compartmentalization of proteins is one manifestation of this departure from equilibrium conditions; the effect of which is now beginning to be elucidated. This should not come as a surprise, as even a cursory inspection of cellular processes reveals the large amount of energetic cost borne to maintain cell-scale patterns, separations and gradients of molecules. The G-proteins, kinases, calcium-responsive proteins have all been shown to contain reaction cycles that are inherently coupled to their signalling activities. G-proteins represent an important and diverse toolset used by cells to generate cellular asymmetries. Many small G-proteins in particular, are dynamically acylated to modify their membrane affinities, or localized in an activity-dependent manner, thus manipulating the mobility modes of these proteins beyond pure diffusion and leading to finely tuned steady state partitioning into cellular membranes. The rates of exchange of small G-proteins over various compartments, as well as their steady state distributions enrich and diversify the landscape of possibilities that GTPase-dependent signalling networks can display over cellular dimensions. The chemical manipulation of spatial cycles represents a new approach for the modulation of cellular signalling with potential therapeutic benefits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.