Evidence map›Paper›PMID 20717032›Full record

ReviewCurrent opinion in otolaryngology & head and neck surgery2010

Cochlear efferent innervation and function.

John J Guinan

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in otolaryngology & head and neck surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 148 citations in OpenAlex.

  1. Differentiating Middle Ear and Medial Olivocochlear Effects on Transient-Evoked Otoacoustic Emissions.Journal of the Association for Research in Otolaryngology : JARO · 2017
    Trial
  2. Trial
  3. Article
  4. Article
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  7. Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024
    Review
  9. Article
  10. Engineering olivocochlear inhibition to reduce acoustic trauma.Molecular therapy. Methods & clinical development · 2023
    Article
  11. Molecular earplugs to protect the inner ear.Molecular therapy. Methods & clinical development · 2023
    Article
  12. Effect of Efferent Stimulation on the Differential Sensitivity in Individuals with Normal Hearing.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  13. Article
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  15. Review
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  19. Article
  20. Distribution of KExperimental neurobiology · 2020
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 2 countries.

John J GuinanEaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA. jjg@epl.meei.harvard.edu
GTx (United States) · US

Funding

Imaging Core PlanP30DC005209 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI LIBERMAN, M. CHARLES · 2002 to 2016
$12.0M
Olivocochlear Reflex in HumansR01DC005977 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI GUINAN, JOHN J · 2003 to 2013
$2.8M
OLIVOCOCHLEAR EFFERENT SYSTEMS AND COCHLEAR PHYSIOLOGYR01DC000235 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUINAN, JOHN J · 1988 to 2012
$2.8M
NIDCD NIH HHS P30 DC005209NIDCD NIH HHS R01 DC000235NIDCD NIH HHS R01 DC005977
6 · The paper itself

Abstract

purpose of reviewThis review covers topics relevant to olivocochlear-efferent anatomy and function for which there are new findings in papers from 2009 to early 2010. RECENT

findingsWork within the review period has increased our understanding of medial olivocochlear (MOC) mechanisms in outer hair cells, MOC-reflex tuning, MOC effects on distortion product otoacoustic emissions, the time course of MOC effects, MOC effects in psychophysical tests and on understanding speech, MOC effects in attention and learning, and lateral efferent function in binaural hearing. In addition, there are new insights into efferent molecular mechanisms and their effect on cochlear development. SUMMARY: Techniques for measuring efferent effects using otoacoustic emissions are now well developed and have promise in clinical applications ranging from predicting which patients are susceptible to acoustic trauma to characterizing relationships between efferent activation and learning disabilities. To realize this promise, studies are needed in which these techniques are applied with high standards.

Indexed as

CochleaEfferent PathwaysHair Cells, AuditoryHumansOlivary Nucleus

Identifiers

PMID20717032
PMCPMC3075443
OpenAlexW2019002614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.