ReviewOxidative medicine and cellular longevity
Forever young: mechanisms of natural anoxia tolerance and potential links to longevity.
Review in Oxidative medicine and cellular longevity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 90 citations in OpenAlex.
- Hypoxia Preserves Chromatin Integrity and Delays Cellular Senescence through Epigenetic Regulation.Biomolecules & therapeutics · 2026Review
- Article
- Forelimb stripe coloration signals age, but not physiological health, in painted turtles.Behavioral ecology and sociobiology · 2026Article
- Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy.International journal of molecular sciences · 2024Review
- Targeting Mitochondrial Homeostasis: The Role of Acupuncture in Depression Treatment.Neuropsychiatric disease and treatment · 2023Review
- Hibernation slows epigenetic ageing in yellow-bellied marmots.Nature ecology & evolution · 2022Article
- New Insights to Regulation of Fructose-1,6-bisphosphatase during Anoxia in Red-Eared Slider,Biomolecules · 2021Article
- Cytoskeletal Arrest: An Anoxia Tolerance Mechanism.Metabolites · 2021Review
- Broiler genetics influences proteome profiles of normal and woody breast muscle.Poultry science · 2021Article
- Transcriptional Analyses of Acute Exposure to Methylmercury on Erythrocytes of Loggerhead Sea Turtle.Toxics · 2021Article
- Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.The protein journal · 2021Article
- Nontraditional systems in aging research: an update.Cellular and molecular life sciences : CMLS · 2021Review
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.Frontiers in cell and developmental biology · 2021Review
- Induction of foxo3a protects turtle neurons against oxidative stress.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2020Article
- Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics.Scientific reports · 2019Article
- Angelica keiskei (Ashitaba) powder and its functional compound xanthoangelol prevent heat stress-induced impairment in sperm density and quality in mouse testes.The Journal of reproduction and development · 2019Article
- Article
- De novo transcriptome assembly of loggerhead sea turtle nesting of the Colombian Caribbean.Genomics data · 2017Article
- An evaluation of the use of pentosidine as a biomarker for ageing turtles.Conservation physiology · 2017Article
- Extension of Health Span and Life Span in Drosophila by S107 Requires the calstabin Homologue FK506-BP2.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While mammals cannot survive oxygen deprivation for more than a few minutes without sustaining severe organ damage, some animals have mastered anaerobic life. Freshwater turtles belonging to the Trachemys and Chrysemys genera are the champion facultative anaerobes of the vertebrate world, often surviving without oxygen for many weeks at a time. The physiological and biochemical mechanisms that underlie anoxia tolerance in turtles include profound metabolic rate depression, post-translational modification of proteins, strong antioxidant defenses, activation of specific stress-responsive transcription factors, and enhanced expression of cytoprotective proteins. Turtles are also known for their incredible longevity and display characteristics of "negligible senescence". We propose that the robust stress-tolerance mechanisms that permit long term anaerobiosis by turtles may also support the longevity of these animals. Many of the mechanisms involved in natural anoxia tolerance, such as hypometabolism or the induction of various protective proteins/pathways, have been shown to play important roles in mammalian oxygen-related diseases and improved understanding of how cells survive without oxygen could aid in the understanding and treatment of various pathological conditions that involve hypoxia or oxidative stress. In the present review we discuss the recent advances made in understanding the molecular nature of anoxia tolerance in turtles and the potential links between this tolerance and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.