ArticleOxidative medicine and cellular longevity
Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence.
Article in Oxidative medicine and cellular longevity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury.Cellular and molecular life sciences : CMLS · 2024Article
- Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue.International journal of molecular sciences · 2021Article
- Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells.Cell death & disease · 2015Article
- NFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis.Molecular biology of the cell · 2013Article
- Klotho acts as a tumor suppressor in cancers.Pathology oncology research : POR · 2013Review
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.The Journal of clinical investigation · 2012Article
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.Preventive medicine · 2012Review
- Aging and the pathogenic response to burn.Aging and disease · 2012Article
- Preventive effects of epigallocatechin-3-O-gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts.Oxidative medicine and cellular longevity · 2012Article
- Reactive oxygen species signaling in cancer: comparison with aging.Aging and disease · 2011Article
- ROS and RNS signaling in heart disorders: could antioxidant treatment be successful?Oxidative medicine and cellular longevity · 2011Review
- Hydroxyl radical and its scavengers in health and disease.Oxidative medicine and cellular longevity · 2011Review
- Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR.Aging and disease · 2010Article
- Deleterious effects of reactive metabolites.Oxidative medicine and cellular longevityReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions.Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development.ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence.Different retarding/stimulating effects of ROS might depend on the nature of signaling species-superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with"super-nucleophilic" properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.