ArticlePhysiological genomics2010
Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 92 citations in OpenAlex.
- Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.BMC genomics · 2026Article
- Canonical Correlation of Milk Composition Parameters and Blood Biomarkers in High-Producing Dairy Cows During Different Lactation Stages.Animals : an open access journal from MDPI · 2024Article
- Effect of β-hydroxybutyrate acid on gene expression levels of antioxidant biomarkers and growth hormone-related genes in liver cell culture.Journal of veterinary research · 2024Article
- Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion.PloS one · 2023Article
- Investigating circulating miRNA in transition dairy cows: What miRNAomics tells about metabolic adaptation.Frontiers in genetics · 2022Article
- Investigation of β-hydroxybutyrate in early lactation of Simmental cows: Genetic parameters and genomic predictions.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Novel Facets of the Liver Transcriptome Are Associated with the Susceptibility and Resistance to Lipid-Related Metabolic Disorders in Periparturient Holstein Cows.Animals : an open access journal from MDPI · 2021Article
- An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake.Scientific reports · 2021Article
- Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Buffalo liver transcriptome analysis suggests immune tolerance as its key adaptive mechanism during early postpartum negative energy balance.Functional & integrative genomics · 2019Article
- Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management.Journal of animal science and biotechnology · 2019Article
- Different mitochondrial DNA copy number in liver and mammary gland of lactating cows with divergent genetic background for milk production.Molecular biology reports · 2018Article
- Article
- Hanging Drop, A Best Three-Dimensional (3D) Culture Method for Primary Buffalo and Sheep Hepatocytes.Scientific reports · 2017Article
- RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-residual feed intake in Nordic dairy cattle.BMC genomics · 2017Article
- Supplements of vitamins B9 and B12 affect hepatic and mammary gland gene expression profiles in lactating dairy cows.BMC genomics · 2016Article
- Liver condition of Holstein cows affects mitochondrial function and fertilization ability of oocytes.The Journal of reproduction and development · 2016Article
- Effect of dietary restriction and subsequent re-alimentation on the transcriptional profile of hepatic tissue in cattle.BMC genomics · 2016Article
- Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis.BMC genomics · 2015Article
- Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
In high-yielding dairy cows the liver undergoes extensive physiological and biochemical changes during the early postpartum period in an effort to re-establish metabolic homeostasis and to counteract the adverse effects of negative energy balance (NEB). These adaptations are likely to be mediated by significant alterations in hepatic gene expression. To gain new insights into these events an energy balance model was created using differential feeding and milking regimes to produce two groups of cows with either a mild (MNEB) or severe NEB (SNEB) status. Cows were slaughtered and liver tissues collected on days 6-7 of the first follicular wave postpartum. Using an Affymetrix 23k oligonucleotide bovine array to determine global gene expression in hepatic tissue of these cows, we found a total of 416 genes (189 up- and 227 downregulated) to be altered by SNEB. Network analysis using Ingenuity Pathway Analysis revealed that SNEB was associated with widespread changes in gene expression classified into 36 gene networks including those associated with lipid metabolism, connective tissue development and function, cell signaling, cell cycle, and metabolic diseases, the three most significant of which are discussed in detail. SNEB cows displayed reduced expression of transcription activators and signal transducers that regulate the expression of genes and gene networks associated with cell signaling and tissue repair. These alterations are linked with increased expression of abnormal cell cycle and cellular proliferation associated pathways. This study provides new information and insights on the effect of SNEB on gene expression in high-yielding Holstein Friesian dairy cows in the early postpartum period.
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