SynthesisHuman reproduction update
Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.
Synthesis in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.Frontiers in endocrinology · 2024Pooled it
- Towards Improving Embryo Prioritization: Parallel Next Generation Sequencing of DNA and RNA from a Single Trophectoderm Biopsy.Scientific reports · 2019Trial
- Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?Reproductive biology and endocrinology : RB&E · 2018Trial
- Trial
- Paclitaxel-mediated Cytoskeletal Stabilization Improves Blastocyst Developmental Competence of Bovine Embryos in Vitro.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- The deleterious effect of bisphenol S on early embryo development of mice.Hormones (Athens, Greece) · 2025Article
- Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities.Human genetics · 2024Article
- Association of Polymorphisms inBiomedicines · 2023Article
- Comprehensive transcriptomic analysis of long non-coding RNAs in bovine ovarian follicles and early embryos.PloS one · 2023Review
- Complexity of human death: its physiological, transcriptomic, and microbiological implications.Frontiers in microbiology · 2023Review
- Oocyte maturation abnormalities - A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility pheneomina.Turkish journal of obstetrics and gynecology · 2022Article
- Aquaporins and Animal Gamete Cryopreservation: Advances and Future Challenges.Animals : an open access journal from MDPI · 2022Review
- RNA editing regulates lncRNA splicing in human early embryo development.PLoS computational biology · 2021Article
- The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.Human reproduction (Oxford, England) · 2021Article
- Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.International journal of molecular sciences · 2020Article
- Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development.Frontiers in bioengineering and biotechnology · 2020Article
- The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.International journal of molecular sciences · 2019Article
- Is there any correlation between apoptotic genes expression in cumulus cells with embryo morphokinetics?Molecular biology reports · 2019Article
- EmExplorer: a database for exploring time activation of gene expression in mammalian embryos.Open biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe first week of human embryonic development comprises a series of events that change highly specialized germ cells into undifferentiated human embryonic stem cells (hESCs) that display an extraordinarily broad developmental potential. The understanding of these events is crucial to the improvement of the success rate of in vitro fertilization. With the emergence of new technologies such as Omics, the gene expression profiling of human oocytes, embryos and hESCs has been performed and generated a flood of data related to the molecular signature of early embryo development.
methodsIn order to understand the complex genetic network that controls the first week of embryo development, we performed a systematic review and study of this issue. We performed a literature search using PubMed and EMBASE to identify all relevant studies published as original articles in English up to March 2010 (n = 165). We also analyzed the transcriptome of human oocytes, embryos and hESCs.
resultsDistinct sets of genes were revealed by comparing the expression profiles of oocytes, embryos on Day 3 and hESCs, which are associated with totipotency, pluripotency and reprogramming properties, respectively. Known components of two signaling pathways (WNT and transforming growth factor-β) were linked to oocyte maturation and early embryonic development.
conclusionsOmics analysis provides tools for understanding the molecular mechanisms and signaling pathways controlling early embryonic development. Furthermore, we discuss the clinical relevance of using a non-invasive molecular approach to embryo selection for the single-embryo transfer program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.