Evidence map›Paper›PMID 20716516›Full record

ReviewNucleic acids research2010

Archaeal/eukaryal RNase P: subunits, functions and RNA diversification.

Nayef Jarrous, Venkat Gopalan

Open access · goldAbstract readReview
In one paragraph

Review in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 115 citations in OpenAlex.

  1. Coevolution of RNase P and the ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. RNase P: Beyond Precursor tRNA Processing.Genomics, proteomics & bioinformatics · 2024
    Review
  6. Review
  7. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. RNase P Inhibitors Identified as Aggregators.Antimicrobial agents and chemotherapy · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Nayef JarrousDepartment of Microbiology and Molecular Genetics, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. jarrous@md.huji.ac.il
Venkat Gopalan
Hebrew University of Jerusalem · ILThe Ohio State University · US

Funding

Structure and Function in Catalytic RNP AssemblyR01GM067807 · NIGMS · OHIO STATE UNIVERSITY · PI FOSTER, MARK P. · 2004 to 2009
$1.7M
Catalytic inactivation of miRNA function by customized RNase P-based ribozymesR21AI082242 · NIAID · OHIO STATE UNIVERSITY · PI GOPALAN, VENKAT, SCHOENBERG, DANIEL R. · 2009 to 2010
$495k
Spatiotemporal Regulation of Brain RNase P as a Basis for Neurological DisordersR21NS096600 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACKERMAN, SUSAN L, GOPALAN, VENKAT · 2016 to 2017
$439k
National Institute of General Medical Sciences R01 GM067807NIAID NIH HHS 1R21 AI082242
6 · The paper itself

Abstract

RNase P, a catalytic ribonucleoprotein (RNP), is best known for its role in precursor tRNA processing. Recent discoveries have revealed that eukaryal RNase P is also required for transcription and processing of select non-coding RNAs, thus enmeshing RNase P in an intricate network of machineries required for gene expression. Moreover, the RNase P RNA seems to have been subject to gene duplication, selection and divergence to generate two new catalytic RNPs, RNase MRP and MRP-TERT, which perform novel functions encompassing cell cycle control and stem cell biology. We present new evidence and perspectives on the functional diversification of the RNase P RNA to highlight it as a paradigm for the evolutionary plasticity that underlies the extant broad repertoire of catalytic and unexpected regulatory roles played by RNA-driven RNPs.

Indexed as

ArchaeaArchaeal ProteinsBacteriaChromatinEndoribonucleasesEukaryotaEvolution, MolecularHumansProtein SubunitsRibonuclease PRNA, CatalyticArchaeal ProteinsChromatinEndoribonucleasesmitochondrial RNA-processing endoribonucleaseProtein SubunitsRibonuclease PRNA, Catalytic

Identifiers

PMID20716516
PMCPMC3001073
OpenAlexW2102920946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.