ArticleEnvironmental health perspectives2010
Selenium and mercury in the Brazilian Amazon: opposing influences on age-related cataracts.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Levels of Trace Elements in the Lens, Aqueous Humour, and Plasma of Cataractous Patients-A Narrative Review.International journal of environmental research and public health · 2022Pooled it
- Comparison of neurobehavioral effects of methylmercury exposure in older and younger adult zebrafish (Danio rerio).Neurotoxicology · 2012Trial
- Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.Progress in retinal and eye research · 2026Review
- Recent Progress in Selenium Nanomedicines for Ocular Diseases.International journal of nanomedicine · 2026Review
- The Potential of Selenium-Based Therapies for Ocular Oxidative Stress.Pharmaceutics · 2024Review
- Visual Characteristics of Adults with Long-Standing History of Dietary Exposure to Mercury in Grassy Narrows First Nation, Canada.International journal of environmental research and public health · 2023Article
- MercuNorth - monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectiveness of the Minamata Convention.International journal of circumpolar health · 2021Article
- Trace elements in muscle tissue of three commercial shark species: Prionace glauca, Carcharhinus falciformis, and Alopias pelagicus off the Manzanillo, Colima coast, Mexico.Environmental science and pollution research international · 2021Article
- Mercury-induced aggregation of human lens γ-crystallins reveals a potential role in cataract disease.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Article
- Concentrations of mercury (Hg) and selenium (Se) in afterbirth and their relations with various factors.Environmental geochemistry and health · 2018Article
- Hair mercury and risk assessment for consumption of contaminated seafood in residents from the coast of the Persian Gulf, Iran.Environmental science and pollution research international · 2018Article
- Article
- Selenium and mercury molar ratios in commercial fish from New Jersey and Illinois: variation within species and relevance to risk communication.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013Article
- Mercury and selenium levels, and selenium:mercury molar ratios of brain, muscle and other tissues in bluefish (Pomatomus saltatrix) from New Jersey, USA.The Science of the total environment · 2013Article
- Article
- Interspecific and intraspecific variation in selenium:mercury molar ratios in saltwater fish from the Aleutians: potential protection on mercury toxicity by selenium.The Science of the total environment · 2012Article
- Article
- Selenium and mercury molar ratios in saltwater fish from New Jersey: individual and species variability complicate use in human health fish consumption advisories.Environmental research · 2012Article
- Biomarkers of methylmercury exposure immunotoxicity among fish consumers in Amazonian Brazil.Environmental health perspectives · 2011Article
- Neurotoxic sequelae of mercury exposure: an intervention and follow-up study in the Brazilian Amazon.EcoHealth · 2011Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAge-related cataracts (ARCs) are an important cause of blindness in developing countries. Although antioxidants may be part of the body's defense to prevent ARC, environmental contaminants may contribute to cataractogenesis. In fish-eating populations of the lower Tapajós region, elevated exposure to mercury (Hg) has been reported, and blood levels of selenium (Se) range from normal to very high (> 1,000 microg/L).
objectivesWe examined ARCs in relation to these elements among adults (> or = 40 years of age) from 12 riverside communities.
methodsParticipants (n = 211) provided blood samples and underwent an extensive ocular examination. Inductively coupled plasma mass spectrometry was used to assess Hg and Se in blood and plasma.
resultsOne-third (n = 69; 32.7%) of the participants had ARC. Lower plasma Se (P-Se; < 25th percentile, 110 microg/L) and higher blood Hg (B-Hg; > or = 25th percentile, 25 microg/L) were associated with a higher prevalence odds ratio (POR) of ARC [adjusted POR (95% confidence interval), 2.69 (1.11-6.56) and 4.45 (1.43-13.83), respectively]. Among participants with high P-Se, we observed a positive but nonsignificant association with high B-Hg exposure, whereas among those with low B-Hg, we observed no association for P-Se. However, compared with the optimum situation (high P-Se, low B-Hg), the POR for those with low P-Se and high B-Hg was 16.4 (3.0-87.9). This finding suggests a synergistic effect.
conclusionOur results suggest that persons in this population with elevated Hg, the cataractogenic effects of Hg may be offset by Se. Because of the relatively small sample size and possible confounding by other dietary nutrients, additional studies with sufficient power to assess multiple nutrient and toxic interactions are required to confirm these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.