ReviewAnnals of the New York Academy of Sciences2010
Oxidants and antioxidants in sulfur mustard-induced injury.
Review in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 144 citations in OpenAlex.
- Delayed complications of sulfur mustard poisoning: a focus on inflammation and telomere footprint.Archives of toxicology · 2025Review
- Delayed complications of sulfur mustard poisoning: a focus on inflammation and telomere footprint.Archives of toxicology · 2025Review
- Long-term pulmonary complications in sulfur mustard-exposed patients: gene expression and DNA methylation of OGG1.BioImpacts : BI · 2025Article
- Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices.Toxicology and applied pharmacology · 2024Article
- Article
- Topical application of synthetic melanin promotes tissue repair.NPJ Regenerative medicine · 2023Article
- Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide.ACS bio & med chem Au · 2023Article
- Skin Models Used to Define Mechanisms of Action of Sulfur Mustard.Disaster medicine and public health preparedness · 2023Review
- Remediation Approaches to Reduce Hydrocarbon Contamination in Petroleum-Polluted Soil.Microorganisms · 2023Article
- Article
- Mustard gas exposure instigates retinal Müller cell gliosis.Experimental eye research · 2023Article
- Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics.Antioxidants (Basel, Switzerland) · 2023Review
- Therapeutic Potential of Mesenchymal Stem Cell-Secreted Factors on Delay in Corneal Wound Healing by Nitrogen Mustard.International journal of molecular sciences · 2022Article
- Ophthalmic Complications and Managements of Sulfur Mustard Exposure: A Narrative Review.Archives of Iranian medicine · 2022Review
- Proteomics analysis of chronic skin injuries caused by mustard gas.BMC medical genomics · 2022Article
- MG53 attenuates nitrogen mustard-induced acute lung injury.Journal of cellular and molecular medicine · 2022Article
- Histopathology Study of Patients with Delayed Mustard Gas Keratopathy 30 Years After Exposure.Iranian journal of pathology · 2022Article
- A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness.Inhalation toxicology · 2022Review
- Possible Treatment Approaches of Sulfur Mustard-Induced Lung Disorders, Experimental and Clinical Evidence, an Updated Review.Frontiers in medicine · 2022Review
- Possible treatment with medicinal herbs and their ingredients of lung disorders induced by sulfur mustard exposures: a review.Environmental science and pollution research international · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Sulfur mustard (SM) is a chemical weapon that targets the skin, eyes, and lung. It was first employed during World War I and it remains a significant military and civilian threat. As a bifunctional alkylating agent, SM reacts with a variety of macromolecules in target tissues including nucleic acids, proteins and lipids, as well as small molecular weight metabolites such as glutathione. By alkylating subcellular components, SM disrupts metabolism, a process that can lead to oxidative stress. Evidence for oxidative stress in tissues exposed to SM or its analogs include increased formation of reactive oxygen species, the presence of lipid peroxidation products and oxidized proteins, and increases in antioxidant enzymes such as superoxide dismutase, catalase, and glutathione-S-transferase. Inhibition of antioxidant enzymes including thioredoxin reductase by SM can also disrupt cellular redox homeostasis. Consistent with these findings, SM-induced toxicity has been shown to be reduced by antioxidants in both in vitro and in vivo models. These data indicate that drugs that target oxidative stress pathways may represent important candidates for reducing SM-induced tissue injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.