ReviewAnnals of the New York Academy of Sciences2010
Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction.
Review in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury.Journal of cellular and molecular medicine · 2026Review
- Skin-derived volatile organic compounds trigger redox signalling pathways in human keratinocytesRSC advances · 2025Article
- Mechanisms and preventive measures of ALDH2 in ischemia‑reperfusion injury: Ferroptosis as a novel target (Review).Molecular medicine reports · 2025Review
- Balancing the dual nature of glycotoxins: interplay of diet, digestion, and gut microbiome.Frontiers in nutrition · 2025Review
- Predicting Chronological Age via the Skin Volatile Profile.Journal of the American Society for Mass Spectrometry · 2024Article
- Mitochondrial Dysfunction-Associated Mechanisms in the Development of Chronic Liver Diseases.Biology · 2023Review
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.PNAS nexus · 2022Article
- Inhibition Mechanism of L-Cysteine on Maillard Reaction by Trapping 5-Hydroxymethylfurfural.Foods (Basel, Switzerland) · 2021Article
- Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products.Biomolecules · 2020Article
- Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast.TheScientificWorldJournal · 2020Article
- Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis.Metabolites · 2019Article
- Mitochondria as a Source and a Target for Uremic Toxins.International journal of molecular sciences · 2019Review
- Lipoxidation targets: From basic mechanisms to pathophysiology.Redox biology · 2019Article
- Review
- Volatile fingerprinting of Pseudomonas aeruginosa and respiratory syncytial virus infection in an in vitro cystic fibrosis co-infection model.Journal of breath research · 2018Article
- Volatile fingerprinting of human respiratory viruses from cell culture.Journal of breath research · 2018Article
- Preferential recognition of auto-antibodies against 4-hydroxynonenal modified DNA in the cancer patients.Journal of clinical laboratory analysis · 2017Article
- Microglia antioxidant systems and redox signalling.British journal of pharmacology · 2017Review
- 4-Hydroxy-2-nonenal: a critical target in oxidative stress?American journal of physiology. Cell physiology · 2016Review
- Redox homeostasis: The Golden Mean of healthy living.Redox biology · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Signaling by H(2)O(2), alpha,beta-unsaturated aldehydes, such as 4-hydroxy-2-nonenal (HNE) and related chemical species, is thought to differ from signaling by other second messengers because the oxidants and other electrophiles can readily undergo nonenzymatic reactions and are therefore classified as "reactive." This brief review will describe how and when the chemistry of signaling is similar or differs from classic second messengers, such as cyclic AMP, or posttranslational signaling, such as farnesylation or ubiquitination. The chemistry of cysteine provides a common factor that underlies signaling by H(2)O(2) and HNE. Nonetheless, as H(2)O(2) and HNE are rapidly metabolized in vivo, spatial considerations are extremely important in their actions. Therefore, the locations of sources of H(2)O(2) and alpha,beta-unsaturated aldehydes, the NADPH oxidases, mitochondria, membrane lipids, and redox cycling toxicants, as well as their targets, are key factors. The activation of the JNK pathway by HNE and endogenously generated H(2)O(2) illustrates these principles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.